In many areas of the United States the battle against tuberculosisis being lost. Two major markers of this failure are the increasingincidence of tuberculosis and the rising prevalence of drug-resistanttuberculous infection. The recent epidemics of multidrug-resistanttuberculosis in several East Coast hospitals and an explosiveoutbreak in the New York state prison system have taken wellin excess of 100 lives1,2. Since 1985, after 35 years of steadilydeclining incidence (with declines averaging 6 percent per year),tuberculosis case rates have increased each year. Direct andindirect epidemiologic data indicate that the human immunodeficiencyvirus (HIV) . . . [Full Text of this Article]
Directly Observed Therapy
Intermittent Regimens
Getting the Job Done
References
Related Letters:
Directly Observed Treatment of Tuberculosis
Hotchkiss R. L., DiFerdinando G. T., Klein S. J., Novick L. F., Perlman D. C., Salomon N., Iseman M. D., Cohn D. L., Sbarbaro J. A.
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N Engl J Med 1993;
329:135-136, Jul 8, 1993.
Correspondence
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