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Correspondence
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Volume 328:581 February 25, 1993 Number 8
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CHOP versus m-BACOD in Non-Hodgkin's Lymphoma

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To the Editor: The results of a randomized trial reported by Gordon et al. (Nov. 5 issue)1 indicate that a chemotherapeutic regimen containing cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and one containing bleomycin, doxorubicin, cyclophosphamide, vincristine, dexamethasone, methotrexate, and leucovorin (m-BACOD) were equivalent in their activity against diffuse advanced non-Hodgkin's lymphoma but that m-BACOD was more toxic. The authors stated that "the normalized dose intensity with CHOP was higher than that with m-BACOD . . . even though the prescribed doses of both cyclophosphamide and doxorubicin were higher in the CHOP regimen." Although the authors then state that "the actual . . . [Full Text of this Article]

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