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Previous Volume 328:628-635 March 4, 1993 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The recognition that the restoration of patency to occluded blood vessels can improve clinical outcomes has led to intense interest in the formation and dissolution of platelet thrombi and in the pathobiologic features of vascular repair after an injury. To study these events in an experimental model, many investigators challenge isolated platelets or endothelium with stimuli that represent physiologic or pathologic mediators, such as thrombin or adenosine diphosphate (ADP), and find that these agonists cause the generation of intracellular mediators that can markedly alter the function of each cell type. A critical facet of thrombus formation and vascular response to . . . [Full Text of this Article]

Platelet Attachment

Release of Endothelium-Derived Platelet Inhibitors

Surface-Bound Endothelial Antiplatelet Factors

Release of Vasoconstrictor and Procoagulant Substances

Endothelial Dysfunction

Atherosclerosis

Diabetes Mellitus, Hypertension, and Other Diseases

Possibilities for Therapeutic Intervention

Conclusions

Discussion

Source Information

From the Department of Medicine, Cardiovascular Division, and the Harvard-Thorndike Laboratories, Beth Israel Hospital, Harvard Medical School, Boston (J.A.W.); and the Departments of Internal Medicine and Pharmacology, University of Iowa College of Medicine, Iowa City (D.D.H.).

Address reprint requests to Dr. Ware at the Cardiovascular Division, RW-453, Beth Israel Hospital, 330 Brookline Ave., Boston, MA 02215.

References

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