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Previous Volume 329:734-735 September 2, 1993 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Treatment of histiocytosis X is palliative at best. It includes corticosteroids, alkylating agents, antimetabolites, vinca alkaloids, and irradiation¹. Since 2-chlorodeoxyadenosine, a purine substrate analogue active against lymphoid cancers,² is toxic to monocytes in vitro,³ and since tissue histiocytes are derived from circulating monocytes as they move from the intravascular space to soft tissues, we administered 2-chlorodeoxyadenosine to a patient with histiocytosis X.

A 33-year-old woman had presented at the age of 15 years with polyuria and polydipsia due to diabetes insipidus. Two years later vesiculopustular lesions developed on her gingiva, scalp, and vagina that were histologically . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Pardanani, A., Phyliky, R. L., Li, C.-Y., Tefferi, A. (2003). 2-Chlorodeoxyadenosine Therapy for Disseminated Langerhans Cell Histiocytosis. Mayo Clin Proc. 78: 301-306 [Abstract]  
• Egeler, R. M., Favara, B. E., van Meurs, M., Laman, J. D., Claassen, E. (1999). Differential In Situ Cytokine Profiles of Langerhans-Like Cells and T Cells in Langerhans Cell Histiocytosis: Abundant Expression of Cytokines Relevant to Disease and Treatment. Blood 94: 4195-4201 [Abstract] [Full Text]  
• Saven, A., Burian, C. (1999). Cladribine Activity in Adult Langerhans-Cell Histiocytosis. Blood 93: 4125-4130 [Abstract] [Full Text]