FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 329:1164-1167 October 14, 1993 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Human infection with Ehrlichia chaffeensis, a recently identified bacterium included in the family Rickettsiaceae,^1,2 results in an acute, generally self-limited, febrile illness associated with cytopenia and hepatic-enzyme abnormalities. Several hundred cases of E. chaffeensis infection have been recognized since 1986, although ehrlichiosis has not been described in patients infected with the human immunodeficiency virus (HIV). We report the course of a fatal seronegative ehrlichial infection in a woman with advanced HIV infection. The infection was diagnosed by light and electron microscopy, immunohistochemical techniques, and the polymerase chain reaction. The potential for successful antimicrobial treatment, combined with the possible absence of . . . [Full Text of this Article]

Case Report

Results

Discussion

Source Information

From the Departments of Pathology (C.D.P., R.L.K., N.W.A., B.G.H.), Laboratory Medicine (C.D.P., W.K.H., B.G.H.), and Family and Community Medicine (D.P.S., K.L.G.), San Francisco General Hospital and University of California, San Francisco; the Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta (J.E.D., B.E.A., K.G.S.); and the Department of Pathology, University of Maryland School of Medicine, Baltimore (J.S.D.).

Address reprint requests to Dr. Herndier at the Department of Pathology, San Francisco General Hospital, Bldg. 3, Rm. 106, San Francisco, CA 94110.

References

This article has been cited by other articles:

• Stevenson, H. L., Jordan, J. M., Peerwani, Z., Wang, H.-Q., Walker, D. H., Ismail, N. (2006). An Intradermal Environment Promotes a Protective Type-1 Response against Lethal Systemic Monocytotropic Ehrlichial Infection.. Infect. Immun. 74: 4856-4864 [Abstract] [Full Text]  
• DEMMA, L. J., HOLMAN, R. C., MCQUISTON, J. H., KREBS, J. W., SWERDLOW, D. L. (2005). EPIDEMIOLOGY OF HUMAN EHRLICHIOSIS AND ANAPLASMOSIS IN THE UNITED STATES, 2001-2002. Am J Trop Med Hyg 73: 400-409 [Abstract] [Full Text]  
• Singu, V., Liu, H., Cheng, C., Ganta, R. R. (2005). Ehrlichia chaffeensis Expresses Macrophage- and Tick Cell-Specific 28-Kilodalton Outer Membrane Proteins. Infect. Immun. 73: 79-87 [Abstract] [Full Text]  
• Stone, J. H., Dierberg, K., Aram, G., Dumler, J. S. (2004). Human Monocytic Ehrlichiosis. JAMA 292: 2263-2270 [Abstract] [Full Text]  
• Ismail, N., Soong, L., McBride, J. W., Valbuena, G., Olano, J. P., Feng, H.-M., Walker, D. H. (2004). Overproduction of TNF-{alpha} by CD8+ Type 1 Cells and Down-Regulation of IFN-{gamma} Production by CD4+ Th1 Cells Contribute to Toxic Shock-Like Syndrome in an Animal Model of Fatal Monocytotropic Ehrlichiosis. J. Immunol. 172: 1786-1800 [Abstract] [Full Text]  
• Ganta, R. R., Cheng, C., Wilkerson, M. J., Chapes, S. K. (2004). Delayed Clearance of Ehrlichia chaffeensis Infection in CD4+ T-Cell Knockout Mice{dagger}. Infect. Immun. 72: 159-167 [Abstract] [Full Text]  
• Paddock, C. D., Childs, J. E. (2003). Ehrlichia chaffeensis: a Prototypical Emerging Pathogen. Clin. Microbiol. Rev. 16: 37-64 [Abstract] [Full Text]  
• Cheng, C., Paddock, C. D., Reddy Ganta, R. (2003). Molecular Heterogeneity of Ehrlichia chaffeensis Isolates Determined by Sequence Analysis of the 28-Kilodalton Outer Membrane Protein Genes and Other Regions of the Genome. Infect. Immun. 71: 187-195 [Abstract] [Full Text]  
• Ganta, R. R., Wilkerson, M. J., Cheng, C., Rokey, A. M., Chapes, S. K. (2002). Persistent Ehrlichia chaffeensis Infection Occurs in the Absence of Functional Major Histocompatibility Complex Class II Genes. Infect. Immun. 70: 380-388 [Abstract] [Full Text]  
• Sotomayor, E. A., Popov, V. L., Feng, H.-M., Walker, D. H., Olano, J. P. (2001). Animal Model of Fatal Human Monocytotropic Ehrlichiosis. Am. J. Pathol. 158: 757-769 [Abstract] [Full Text]  
• Shu-yi Li, J., Yager, E., Reilly, M., Freeman, C., Reddy, G. R., Reilly, A. A., Chu, F. K., Winslow, G. M. (2001). Outer Membrane Protein-Specific Monoclonal Antibodies Protect SCID Mice from Fatal Infection by the Obligate Intracellular Bacterial Pathogen Ehrlichia chaffeensis. J. Immunol. 166: 1855-1862 [Abstract] [Full Text]  
• Yu, X.-J., Crocquet-Valdes, P. A., Cullman, L. C., Popov, V. L., Walker, D. H. (1999). Comparison of Ehrlichia chaffeensis Recombinant Proteins for Serologic Diagnosis of Human Monocytotropic Ehrlichiosis. J. Clin. Microbiol. 37: 2568-2575 [Abstract] [Full Text]  
• Winslow, G. M., Yager, E., Shilo, K., Collins, D. N., Chu, F. K. (1998). Infection of the Laboratory Mouse with the Intracellular Pathogen Ehrlichia chaffeensis. Infect. Immun. 66: 3892-3899 [Abstract] [Full Text]  
• Czachor, J. S., Gleckman, R. A. (1995). Selective Causes of Fever in Adult Human Immunodeficiency Virus--Infected Patients Relative to CD4+ Cell Counts. Arch Fam Med 4: 879-884 [Abstract]  
• Bakken, J. S., Dumler, J. S., Chen, S.-M., Eckman, M. R., Van Etta, L. L., Walker, D. H. (1994). Human Granulocytic Ehrlichiosis in the Upper Midwest United States: A New Species Emerging?. JAMA 272: 212-218 [Abstract]