Osteonecrosis, or nontraumatic (aseptic, avascular) bone necrosis,is a relatively common disorder estimated to account for morethan 10 percent of all joint replacements1. Although a numberof clinical entities have been associated with osteonecrosis(e.g., Gaucher's disease, systemic lupus erythematosus, rheumatoidarthritis, hemoglobinopathies, air embolism, pancreatitis, andchronic alcoholism), the incidence and pathogenesis of osteonecrosisin each condition are not well defined. Some patients with osteonecrosishave also been treated with corticosteroids. It is not clear,however, if osteonecrosis in patients treated with corticosteroidsrepresents a drug complication, a complication of the diseaseprocess, or both1,2,3,4,5.
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