FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 329:1318-1327 October 28, 1993 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

The crucial differences between normal cells and cancer cells stem from discrete changes in specific genes controlling proliferation and tissue homeostasis. Over 100 such cancer-related genes have been discovered, several of which are implicated in the natural history of human cancer because they are consistently found to be mutated in tumors. The p53 tumor-suppressor gene is the most striking example because it is mutated in about half of almost all types of cancer arising from a wide spectrum of tissues. Other tumor-suppressor genes important in human cancers, such as adenomatous polyposis coli, Wilms' tumor type 1, and neurofibromatosis type 1, . . . [Full Text of this Article]

Molecular Mechanisms of p53 Function

Regulation of Transcription of Multiple Genes by the p53 Protein

Clues to the Mechanisms of Cancer Formation from p53 Mutation Patterns in Tumors

Molecular Archaeology: Analysis of Damage to the p53 Gene in Tumors as a Way of Investigating Causes of Cancer

p53 Mutation Profiles in Human Tumors

            Hepatocellular Carcinoma

            Squamous-Cell Carcinoma of the Skin

Approaches to Molecular Diagnosis, Prognosis, and Therapy

Correlation between the Accumulation of p53 Protein in Neoplastic Cells and the Presence of a Missense Mutation in the p53 Gene

Genetic Screening for Germline p53 Mutations

Immunocytochemical Staining with p53 Antibodies: Biomarker for Cancer

New Diagnostic Strategies Based on the Detection of p53 Antibodies in the Serum of Patients with Cancer

Prognostic Importance of p53 Mutations

Therapy Based on the Renewal of p53 Function

Source Information

From the National Cancer Institute, Laboratory of Human Carcinogenesis, Bethesda, Md. (C.C.H.), and the Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer (World Health Organization), Lyons, France (M.H.).

Address reprint requests to Dr. Harris at the National Cancer Institute, Laboratory of Human Carcinogenesis, Bldg. 37, Rm. 2C01, Bethesda, MD 20892.

References

Related Letters:

Clinical Implications of the p53 Tumor-Suppressor Gene
Rutz H. P., Mirimanoff R. O., Bokemeyer C., Kuczyk M. A., Sehrt J., Muller M., Volkmann M., Zentgraf H., Galle P. R.
Extract | Full Text  
N Engl J Med 1994; 330:864-865, Mar 24, 1994. Correspondence

This article has been cited by other articles:

• Nahi, H., Hagglund, H., Ahlgren, T., Bernell, P., Hardling, M., Karlsson, K., Lazarevic, V. L., Linderholm, M., Smedmyr, B., Astrom, M., Hallbook, H. (2008). An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia: a multi-center study of 381 patients. haematol 93: 1734-1738 [Abstract] [Full Text]  
• Orre, L. M., Pernemalm, M., Lengqvist, J., Lewensohn, R., Lehtio, J. (2007). Up-regulation, Modification, and Translocation of S100A6 Induced by Exposure to Ionizing Radiation Revealed by Proteomics Profiling. Mol. Cell. Proteomics 6: 2122-2131 [Abstract] [Full Text]  
• Ju, J., Schmitz, J. C., Song, B., Kudo, K., Chu, E. (2007). Regulation of p53 Expression in Response to 5-Fluorouracil in Human Cancer RKO Cells. Clin. Cancer Res. 13: 4245-4251 [Abstract] [Full Text]  
• Chen, K., Hu, Z., Wang, L.-E, Zhang, W., El-Naggar, A. K., Sturgis, E. M., Wei, Q. (2007). Polymorphic TP53BP1 and TP53 Gene Interactions Associated with Risk of Squamous Cell Carcinoma of the Head and Neck. Clin. Cancer Res. 13: 4300-4305 [Abstract] [Full Text]  
• Gebitekin, C., Bayram, A. S, Tunca, B., Balaban, S. A (2007). Clinical Significance of p53 Gene Mutation in T1-2N0 Non-Small Cell Lung Cancer. Asian Cardiovasc. Thorac. Ann. 15: 35-38 [Abstract] [Full Text]  
• Hamstra, D. A., Bhojani, M. S., Griffin, L. B., Laxman, B., Ross, B. D., Rehemtulla, A. (2006). Real-time Evaluation of p53 Oscillatory Behavior In vivo Using Bioluminescent Imaging.. Cancer Res. 66: 7482-7489 [Abstract] [Full Text]  
• Ma, H., Hu, Z., Zhai, X., Wang, S., Wang, X., Qin, J., Chen, W., Jin, G., Liu, J., Gao, J., Wang, X., Wei, Q., Shen, H. (2006). Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population. Carcinogenesis 27: 766-771 [Abstract] [Full Text]  
• Hershey, A. E., Dubielzig, R. R., Padilla, M. L., Helfand, S. C. (2005). Aberrant p53 Expression in Feline Vaccine-associated Sarcomas and Correlation with Prognosis. Vet Pathol 42: 805-811 [Abstract] [Full Text]  
• Kim, W.-J., Kim, E.-J., Jeong, P., Quan, C., Kim, J., Li, Q.-L., Yang, J.-O., Ito, Y., Bae, S.-C. (2005). RUNX3 Inactivation by Point Mutations and Aberrant DNA Methylation in Bladder Tumors. Cancer Res. 65: 9347-9354 [Abstract] [Full Text]  
• Jen, K.-Y., Cheung, V. G. (2005). Identification of Novel p53 Target Genes in Ionizing Radiation Response. Cancer Res. 65: 7666-7673 [Abstract] [Full Text]  
• Janni, W., Rack, B., Lindemann, K., Harbeck, N. (2005). Detection of Micrometastatic Disease in Bone Marrow: Is It Ready for Prime Time?. The Oncologist 10: 480-492 [Abstract] [Full Text]  
• Guicciardi, M E, Gores, G J (2005). Apoptosis: a mechanism of acute and chronic liver injury. Gut 54: 1024-1033 [Full Text]  
• Oh, S. J., Ju, J., Kim, B. C., Ko, E., Hong, B. J., Park, J.-G., Park, J. W., Choi, K. Y. (2005). DNA microarrays on a dendron-modified surface improve significantly the detection of single nucleotide variations in the p53 gene. Nucleic Acids Res 33: e90-e90 [Abstract] [Full Text]  
• Mukhopadhyay, U. K., Senderowicz, A. M., Ferbeyre, G. (2005). RNA Silencing of Checkpoint Regulators Sensitizes p53-Defective Prostate Cancer Cells to Chemotherapy while Sparing Normal Cells. Cancer Res. 65: 2872-2881 [Abstract] [Full Text]  
• Chen, A. Y., Shih, S.-J., Garriques, L. N., Rothenberg, M. L., Hsiao, M., Curran, D. P. (2005). Silatecan DB-67 is a novel DNA topoisomerase I-targeted radiation sensitizer. Molecular Cancer Therapeutics 4: 317-324 [Abstract] [Full Text]  
• Chatterjee, S. J., Datar, R., Youssefzadeh, D., George, B., Goebell, P. J., Stein, J. P., Young, L., Shi, S.-R., Gee, C., Groshen, S., Skinner, D. G., Cote, R. J. (2004). Combined Effects of p53, p21, and pRb Expression in the Progression of Bladder Transitional Cell Carcinoma. JCO 22: 1007-1013 [Abstract] [Full Text]  
• Shiraishi, K., Kato, S., Han, S.-Y., Liu, W., Otsuka, K., Sakayori, M., Ishida, T., Takeda, M., Kanamaru, R., Ohuchi, N., Ishioka, C. (2004). Isolation of Temperature-sensitive p53 Mutations from a Comprehensive Missense Mutation Library. J. Biol. Chem. 279: 348-355 [Abstract] [Full Text]  
• Bielas, J. H., Heddle, J. A. (2003). Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells. Proc. Natl. Acad. Sci. USA 100: 12853-12858 [Abstract] [Full Text]  
• Kato, S., Han, S.-Y., Liu, W., Otsuka, K., Shibata, H., Kanamaru, R., Ishioka, C. (2003). Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc. Natl. Acad. Sci. USA 100: 8424-8429 [Abstract] [Full Text]  
• VAN DER MEER-VAN KRAAIJ, C., VAN LIESHOUT, E. M. M., KRAMER, E., VAN DER MEER, R., KEIJER, J. (2003). Mucosal pentraxin (Mptx), a novel rat gene 10-fold down-regulated in colon by dietary heme. FASEB J. 17: 1277-1285 [Abstract] [Full Text]  
• Goldman, R., Shields, P. G. (2003). Food Mutagens. J. Nutr. 133: 965S-973 [Abstract] [Full Text]  
• Gilchrist, D. M. (2002). Medical genetics: 3. An approach to the adult with a genetic disorder. CMAJ 167: 1021-1029 [Abstract] [Full Text]  
• Chen, H. H. W., Su, W.-C., Guo, H.-R., Chang, T.-W., Lee, W.-Y. (2002). p53 and c-erbB-2 but Not bcl-2 are Predictive of Metastasis-free Survival in Breast Cancer Patients Receiving Post-mastectomy Adjuvant Radiotherapy in Taiwan. Jpn J Clin Oncol 32: 332-339 [Abstract] [Full Text]  
• Yamasawa, K., Nio, Y., Dong, M., Yamaguchi, K., Itakura, M. (2002). Clinicopathological Significance of Abnormalities in Gadd45 Expression and Its Relationship to p53 in Human Pancreatic Cancer. Clin. Cancer Res. 8: 2563-2569 [Abstract] [Full Text]  
• Smith, G., Carey, F. A., Beattie, J., Wilkie, M. J. V., Lightfoot, T. J., Coxhead, J., Garner, R. C., Steele, R. J. C., Wolf, C. R. (2002). Mutations in APC, Kirsten-ras, and p53---alternative genetic pathways to colorectal cancer. Proc. Natl. Acad. Sci. USA 99: 9433-9438 [Abstract] [Full Text]  
• Claudio, P. P., Zamparelli, A., Garcia, F. U., Claudio, L., Ammirati, G., Farina, A., Bovicelli, A., Russo, G., Giordano, G. G., McGinnis, D. E., Giordano, A., Cardi, G. (2002). Expression of Cell-Cycle-regulated Proteins pRb2/p130, p107, p27kip1, p53, mdm-2, and Ki-67 (MIB-1) in Prostatic Gland Adenocarcinoma. Clin. Cancer Res. 8: 1808-1815 [Abstract] [Full Text]  
• Melle, C., Nasheuer, H.-P. (2002). Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase {alpha}-primase. Nucleic Acids Res 30: 1493-1499 [Abstract] [Full Text]  
• de Jong, M M, Nolte, I M, te Meerman, G J, van der Graaf, W T A, Oosterwijk, J C, Kleibeuker, J H, Schaapveld, M, de Vries, E G E (2002). Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility. J. Med. Genet. 39: 225-242 [Abstract] [Full Text]  
• Pollack, I. F., Finkelstein, S. D., Woods, J., Burnham, J., Holmes, E. J., Hamilton, R. L., Yates, A. J., Boyett, J. M., Finlay, J. L., Sposto, R., the Children's Cancer Group, (2002). Expression of p53 and Prognosis in Children with Malignant Gliomas. NEJM 346: 420-427 [Abstract] [Full Text]  
• Carroll, J. L., Nielsen, L. L., Pruett, S. B., Mathis, J. M. (2001). The Role of Natural Killer Cells in Adenovirus-mediated p53 Gene Therapy. Molecular Cancer Therapeutics 1: 49-60 [Abstract] [Full Text]  
• Pollack, I. F., Finkelstein, S. D., Burnham, J., Holmes, E. J., Hamilton, R. L., Yates, A. J., Finlay, J. L., Sposto, R. (2001). Age and TP53 Mutation Frequency in Childhood Malignant Gliomas: Results in a Multi-institutional Cohort. Cancer Res. 61: 7404-7407 [Abstract] [Full Text]  
• Jaiswal, M., LaRusso, N. F., Gores, G. J. (2001). Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G626-G634 [Abstract] [Full Text]  
• Robinson, B. W., Shewach, D. S. (2001). Radiosensitization by Gemcitabine in p53 Wild-Type and Mutant MCF-7 Breast Carcinoma Cell Lines. Clin. Cancer Res. 7: 2581-2589 [Abstract] [Full Text]  
• Liu, Y., Asch, H., Kulesz-Martin, M. F. (2001). Functional Quantification of DNA-binding Proteins p53 and Estrogen Receptor in Cells and Tumor Tissues by DNA Affinity Immunoblotting. Cancer Res. 61: 5402-5406 [Abstract] [Full Text]  
• Liu, Y., Kulesz-Martin, M. (2001). p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding. Carcinogenesis 22: 851-860 [Abstract] [Full Text]  
• Christiansen, D. H., Andersen, M. K., Pedersen-Bjergaard, J. (2001). Mutations With Loss of Heterozygosity of p53 Are Common in Therapy-Related Myelodysplasia and Acute Myeloid Leukemia After Exposure to Alkylating Agents and Significantly Associated With Deletion or Loss of 5q, a Complex Karyotype, and a Poor Prognosis. JCO 19: 1405-1413 [Abstract] [Full Text]  
• Tada, M., Furuuchi, K., Kaneda, M., Matsumoto, J., Takahashi, M., Hirai, A., Mitsumoto, Y., Iggo, R. D, Moriuchi, T. (2001). Inactivate the remaining p53 allele or the alternate p73? Preferential selection of the Arg72 polymorphism in cancers with recessive p53 mutants but not transdominant mutants. Carcinogenesis 22: 515-517 [Abstract] [Full Text]  
• Nambiar, P. R., Jackson, M. L., Ellis, J. A., Chelack, B. J., Kidney, B. A., Haines, D. M. (2001). Immunohistochemical Detection of Tumor Suppressor Gene p53 Protein in Feline Injection Site-associated Sarcomas. Vet Pathol 38: 236-238 [Abstract] [Full Text]  
• Bénistant, C., Bourgaux, J.-F., Chapuis, H., Mottet, N., Roche, S., Bali, J.-P. (2001). The COOH-Terminal Src Kinase Csk Is a Tumor Antigen in Human Carcinoma. Cancer Res. 61: 1415-1420 [Abstract] [Full Text]  
• De Hertog, S. A.E., Wensveen, C. A.H., Bastiaens, M. T., Kielich, C. J., Berkhout, M. J.P., Westendorp, R. G.J., Vermeer, B. J., Bouwes Bavinck, J. N. (2001). Relation Between Smoking and Skin Cancer. JCO 19: 231-238 [Abstract] [Full Text]  
• Seewaldt, V. L., Mrózek, K., Dietze, E. C., Parker, M., Caldwell, L. E. (2001). Human Papillomavirus Type 16 E6 Inactivation of p53 in Normal Human Mammary Epithelial Cells Promotes Tamoxifen-mediated Apoptosis. Cancer Res. 61: 616-624 [Abstract] [Full Text]  
• Brantley, M. A. Jr., Harbour, J. W. (2000). Deregulation of the Rb and p53 Pathways in Uveal Melanoma. Am. J. Pathol. 157: 1795-1801 [Abstract] [Full Text]  
• Hashimoto, T., Tokuchi, Y., Hayashi, M., Kobayashi, Y., Nishida, K., Hayashi, S.-i., Ishikawa, Y., Nakagawa, K., Hayashi, J.-i., Tsuchiya, E. (2000). Different Subtypes of Human Lung Adenocarcinoma Caused by Different Etiological Factors : Evidence from p53 Mutational Spectra. Am. J. Pathol. 157: 2133-2141 [Abstract] [Full Text]  
• Jeng, K.-S., Sheen, I-S., Chen, B.-F., Wu, J.-Y. (2000). Is the p53 Gene Mutation of Prognostic Value in Hepatocellular Carcinoma After Resection?. Arch Surg 135: 1329-1333 [Abstract] [Full Text]  
• Mizobuchi, S., Furihata, M., Sonobe, H., Ohtsuki, Y., Ishikawa, T., Murakami, H., Kurabayashi, A., Ogoshi, S., Sasaguri, S. (2000). Association Between p53 Immunostaining and Cigarette Smoking in Squamous Cell Carcinoma of the Esophagus. Jpn J Clin Oncol 30: 423-428 [Abstract] [Full Text]  
• Sesink, A. L.A., Termont, D. S.M.L., Kleibeuker, J. H., Van der Meer, R. (2000). Red meat and colon cancer: dietary haem, but not fat, has cytotoxic and hyperproliferative effects on rat colonic epithelium. Carcinogenesis 21: 1909-1915 [Abstract] [Full Text]  
• Khabir, A., Sellami, A., Sakka, M., Ghorbel, A. M., Daoud, J., Frikha, M., Drira, M. M., Busson, P., Jlidi, R. (2000). Contrasted Frequencies of p53 Accumulation in the Two Age Groups of North African Nasopharyngeal Carcinomas. Clin. Cancer Res. 6: 3932-3936 [Abstract] [Full Text]  
• Smyth, M. J., Thia, K. Y.T., Street, S. E.A., MacGregor, D., Godfrey, D. I., Trapani, J. A. (2000). Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma. JEM 192: 755-760 [Abstract] [Full Text]  
• Mouriaux, F., Maurage, C.-A., Labalette, P., Sablonnière, B., Malecaze, F., Darbon, J.-M. (2000). Cyclin-Dependent Kinase Inhibitory Protein Expression in Human Choroidal Melanoma Tumors. IOVS 41: 2837-2843 [Abstract] [Full Text]  
• Fabian, C. J., Kimler, B. F., Zalles, C. M., Klemp, J. R., Kamel, S., Zeiger, S., Mayo, M. S. (2000). Short-Term Breast Cancer Prediction by Random Periareolar Fine-Needle Aspiration Cytology and the Gail Risk Model. JNCI J Natl Cancer Inst 92: 1217-1227 [Abstract] [Full Text]  
• Schneider, P. M., Stoeltzing, O., Roth, J. A., Hoelscher, A. H., Wegerer, S., Mizumoto, S., Becker, K., Dittler, H.-J., Fink, U., Siewert, J. R. (2000). p53 Mutational Status Improves Estimation of Prognosis in Patients with Curatively Resected Adenocarcinoma in Barrett's Esophagus. Clin. Cancer Res. 6: 3153-3158 [Abstract] [Full Text]  
• Dreyfus, D. H., Nagasawa, M., Kelleher, C. A., Gelfand, E. W. (2000). Stable expression of Epstein-Barr virus BZLF-1-encoded ZEBRA protein activates p53-dependent transcription in human Jurkat T-lymphoblastoid cells. Blood 96: 625-634 [Abstract] [Full Text]  
• Shields, P. G., Harris, C. C. (2000). Cancer Risk and Low-Penetrance Susceptibility Genes in Gene-Environment Interactions. JCO 18: 2309-2315 [Abstract] [Full Text]  
• Wilson, V. L., Yin, X., Thompson, B., Wade, K. R., Watkins, J. P., Wei, Q., Lee, W. R. (2000). Oncogenic Base Substitution Mutations in Circulating Leukocytes of Normal Individuals. Cancer Res. 60: 1830-1834 [Abstract] [Full Text]  
• Carson, H. J., Lueck, N. E., Horten, B. C. (2000). Comparison of Mutant and Wild-Type p53 Proteins in Merkel Cell Carcinoma. CVI 7: 326-326 [Full Text]  
• Luna, M. C., Ferrario, A., Wong, S., Fisher, A. M. R., Gomer, C. J. (2000). Photodynamic Therapy-mediated Oxidative Stress as a Molecular Switch for the Temporal Expression of Genes Ligated to the Human Heat Shock Promoter. Cancer Res. 60: 1637-1644 [Abstract] [Full Text]  
• Inazuka, M., Tahira, T., Horiuchi, T., Harashima, S., Sawabe, T., Kondo, M., Miyahara, H., Hayashi, K. (2000). Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium. Rheumatology (Oxford) 39: 262-266 [Abstract] [Full Text]  
• Nemunaitis, J., Swisher, S. G., Timmons, T., Connors, D., Mack, M., Doerksen, L., Weill, D., Wait, J., Lawrence, D. D., Kemp, B. L., Fossella, F., Glisson, B. S., Hong, W. K., Khuri, F. R., Kurie, J. M., Lee, J. J., Lee, J. S., Nguyen, D. M., Nesbitt, J. C., Perez-Soler, R., Pisters, K. M. W., Putnam, J. B., Richli, W. R., Shin, D. M., Walsh, G. L., Merritt, J., Roth, J. (2000). Adenovirus-Mediated p53 Gene Transfer in Sequence With Cisplatin to Tumors of Patients With Non-Small-Cell Lung Cancer. JCO 18: 609-609 [Abstract] [Full Text]  
• Servomaa, K, Kiuru, A, Kosma, V-M, Hirvikoski, P, Rytömaa, T (2000). p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women. Mol. Pathol. 53: 24-30 [Abstract] [Full Text]  
• Powell, B., Soong, R., Iacopetta, B., Seshadri, R., Smith, D. R. (2000). Prognostic Significance of Mutations to Different Structural and Functional Regions of the p53 Gene in Breast Cancer. Clin. Cancer Res. 6: 443-451 [Abstract] [Full Text]  
• Vikhanskaya, F., D'Incalci, M., Broggini, M. (2000). p73 competes with p53 and attenuates its response in a human ovarian cancer cell line. Nucleic Acids Res 28: 513-519 [Abstract] [Full Text]  
• Shin, D. M., Mao, L., Papadimitrakopoulou, V. M., Clayman, G., El-Naggar, A., Shin, H. J. C., Lee, J. J., Lee, J. S., Gillenwater, A., Myers, J., Lippman, S. M., Hittelman, W. N., Hong, W. K. (2000). Biochemopreventive Therapy for Patients With Premalignant Lesions of the Head and Neck and p53 Gene Expression. JNCI J Natl Cancer Inst 92: 69-73 [Full Text]  
• Schwartz, J. L. (2000). Biomarkers and Molecular Epidemiology and Chemoprevention of Oral Carcinogenesis. CROBM 11: 92-122 [Abstract] [Full Text]  
• Ginn, P. E., Fox, L. E., Brower, J. C., Gaskin, A., Kurzman, I. D., Kubilis, P. S. (2000). Immunohistochemical Detection of p53 Tumor-Suppressor Protein is a Poor Indicator of Prognosis for Canine Cutaneous Mast Cell Tumors. Vet Pathol 37: 33-39 [Abstract] [Full Text]  
• Lukas, J., Niu, N., Press, M. F. (2000). p53 Mutations and Expression in Breast Carcinoma in Situ. Am. J. Pathol. 156: 183-191 [Abstract] [Full Text]  
• Bell, D. W., Varley, J. M., Szydlo, T. E., Kang, D. H., Wahrer, D. C., Shannon, K. E., Lubratovich, M., Verselis, S. J., Isselbacher, K. J., Fraumeni, J. F., Birch, J. M., Li, F. P., Garber, J. E., Haber, D. A. (1999). Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome. Science 286: 2528-2531 [Abstract] [Full Text]  
• Grace, M. J., Xie, L., Musco, M. L., Cui, S., Gurnani, M., DiGiacomo, R., Chang, A., Indelicato, S., Syed, J., Johnson, R., Nielsen, L. L. (1999). The Use of Laser Scanning Cytometry to Assess Depth of Penetration of Adenovirus p53 Gene Therapy in Human Xenograft Biopsies. Am. J. Pathol. 155: 1869-1878 [Abstract] [Full Text]  
• Kohmura, T., Hasegawa, Y., Ogawa, T., Matsuura, H., Takahashi, M., Yanagita, N., Nakashima, T. (1999). Cyclin D1 and p53 Overexpression Predicts Multiple Primary Malignant Neoplasms of the Hypopharynx and Esophagus. Arch Otolaryngol Head Neck Surg 125: 1351-1354 [Abstract] [Full Text]  
• Lassaletta, L., Brandariz, J. A., Benito, A., de la Cruz, J., Gomez, C., Ballestin, C., Hitt, R., Colomer, R., Alvarez-Vicent, J. J. (1999). p53 Expression in Locally Advanced Pharyngeal Squamous Cell Carcinoma. Arch Otolaryngol Head Neck Surg 125: 1356-1359 [Abstract] [Full Text]  
• Fang, L., Lee, S. W., Aaronson, S. A. (1999). Comparative Analysis of P73 and P53 Regulation and Effector Functions. JCB 147: 823-830 [Abstract] [Full Text]  
• Hashimoto, T., Tokuchi, Y., Hayashi, M., Kobayashi, Y., Nishida, K., Hayashi, S.-i., Ishikawa, Y., Tsuchiya, S., Nakagawa, K., Hayashi, J.-i., Tsuchiya, E. (1999). p53 Null Mutations Undetected by Immunohistochemical Staining Predict a Poor Outcome with Early-Stage Non-Small Cell Lung Carcinomas. Cancer Res. 59: 5572-5577 [Abstract] [Full Text]  
• Rohayem, J., Conrad, K., Zimmermann, T., Frank, K.-H. (1999). Comparison of the Diagnostic Accuracy of Three Commercially Available Enzyme Immunoassays for Anti-p53 Antibodies. Clin. Chem. 45: 2014-2016 [Full Text]  
• Marutani, M., Tonoki, H., Tada, M., Takahashi, M., Kashiwazaki, H., Hida, Y., Hamada, J.-i., Asaka, M., Moriuchi, T. (1999). Dominant-Negative Mutations of the Tumor Suppressor p53 Relating to Early Onset of Glioblastoma Multiforme. Cancer Res. 59: 4765-4769 [Abstract] [Full Text]  
• Kikukawa, M., Aoki, N., Sakamoto, Y., Mori, M. (1999). Study of p53 in Elderly Patients with Myelodysplastic Syndromes by Immunohistochemistry and DNA Analysis. Am. J. Pathol. 155: 717-721 [Abstract] [Full Text]  
• Wakamatsu, K., Nakanishi, Y., Takayama, K., Miyazaki, H., Hayashi, K., Hara, N. (1999). Frequent Expression of p53 Protein without Mutation in the Atypical Epithelium of Human Bronchus. Am. J. Respir. Cell Mol. Bio. 21: 209-215 [Abstract] [Full Text]  
• Tannapfel, A., Wasner, M., Krause, K., Geissler, F., Katalinic, A., Hauss, J., Mossner, J., Engeland, K., Wittekind, C. (1999). Expression of p73 and Its Relation to Histopathology and Prognosis in Hepatocellular Carcinoma. JNCI J Natl Cancer Inst 91: 1154-1158 [Abstract] [Full Text]  
• Mejia, C., Pellin, A., Navarro, S., Castel, V., Llombart-Bosch, A. (1999). A New Mutation of the p53 Gene in Human Neuroblastoma, Not Correlated with N-myc Amplification. INT J SURG PATHOL 7: 149-154 [Abstract]  
• Ahrendt, S. A., Halachmi, S., Chow, J. T., Wu, L., Halachmi, N., Yang, S. C., Wehage, S., Jen, J., Sidransky, D. (1999). Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array. Proc. Natl. Acad. Sci. USA 96: 7382-7387 [Abstract] [Full Text]  
• Koppaka, V., Silvestro, L., Engler, J. A., Brouillette, C. G., Axelsen, P. H. (1999). The Structure of Human Lipoprotein A-I. EVIDENCE FOR THE "BELT" MODEL. J. Biol. Chem. 274: 14541-14544 [Abstract] [Full Text]  
• Luch, A., Kudla, K., Seidel, A., Doehmer, J., Greim, H., Baird, W. M. (1999). The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (–)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determined the effect on the proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7. Carcinogenesis 20: 859-865 [Abstract] [Full Text]  
• Bellas, R. E., Sonenshein, G. E. (1999). Nuclear Factor {{kappa}}B Cooperates with c-Myc in Promoting Murine Hepatocyte Survival in a Manner Independentof p53 Tumor Suppressor Function. Cell Growth Differ. 10: 287-294 [Abstract] [Full Text]  
• Kelavkar, U. P., Badr, K. F. (1999). Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: Evidence that 15-lipoxygenase is a mutator gene. Proc. Natl. Acad. Sci. USA 96: 4378-4383 [Abstract] [Full Text]  
• Kaelin, W. G. Jr. (1999). The Emerging p53 Gene Family. JNCI J Natl Cancer Inst 91: 594-598 [Abstract] [Full Text]  
• Gammon, M. D., Hibshoosh, H., Terry, M. B., Bose, S., Schoenberg, J. B., Brinton, L. A., Bernstein, J. L., Thompson, W. D. (1999). Cigarette Smoking and Other Risk Factors in Relation to p53 Expression in Breast Cancer among Young Women. Cancer Epidemiol. Biomarkers Prev. 8: 255-263 [Abstract] [Full Text]  
• Kressner, U., Inganas, M., Byding, S., Blikstad, I., Pahlman, L., Glimelius, B., Lindmark, G. (1999). Prognostic Value of p53 Genetic Changes in Colorectal Cancer. JCO 17: 593-593 [Abstract] [Full Text]  
• Chu, E., Copur, S. M., Ju, J., Chen, T.-m., Khleif, S., Voeller, D. M., Mizunuma, N., Patel, M., Maley, G. F., Maley, F., Allegra, C. J. (1999). Thymidylate Synthase Protein and p53 mRNA Form an In Vivo Ribonucleoprotein Complex. Mol. Cell. Biol. 19: 1582-1594 [Abstract] [Full Text]  
• Fisher, A. M. R., Ferrario, A., Rucker, N., Zhang, S., Gomer, C. J. (1999). Photodynamic Therapy Sensitivity Is Not Altered in Human Tumor Cells after Abrogation of p53 Function. Cancer Res. 59: 331-335 [Abstract] [Full Text]  
• Smith, D. F., Whitesell, L., Katsanis, E. (1998). Molecular Chaperones: Biology and Prospects for Pharmacological Intervention. Pharmacol. Rev. 50: 493-514 [Abstract] [Full Text]  
• Wijnhoven, S. W. P., Van Sloun, P. P. H., Kool, H. J. M., Weeda, G., Slater, R., Lohman, P. H. M., van Zeeland, A. A., Vrieling, H. (1998). Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse. Proc. Natl. Acad. Sci. USA 95: 13759-13764 [Abstract] [Full Text]  
• DeMuth, J. P., Jackson, C. M., Weaver, D. A., Crawford, E. L., Durzinsky, D. S., Durham, S. J., Zaher, A., Phillips, E. R., Khuder, S. A., Willey, J. C. (1998). The Gene Expression Index c-myc × E2F-1/p21 Is Highly Predictive of Malignant Phenotype in Human Bronchial Epithelial Cells. Am. J. Respir. Cell Mol. Bio. 19: 18-24 [Abstract] [Full Text]  
• Wu, M., Bellas, R. E., Shen, J., Sonenshein, G. E. (1998). Roles of the Tumor Suppressor p53 and the Cyclin-dependent Kinase Inhibitor p21WAF1/CIP1 in Receptor-mediated Apoptosis of WEHI 231 B Lymphoma Cells. JEM 187: 1671-1679 [Abstract] [Full Text]  
• Ohlsson, C., Kley, N., Werner, H., LeRoith, D. (1998). p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1. Endocrinology 139: 1101-1107 [Abstract] [Full Text]  
• Benini, E., Costa, A., Abolafio, G., Silvestrini, R. (1998). p53 Expression in Human Carcinomas: Could Flow Cytometry Be an Alternative to Immunohistochemistry?. J. Histochem. Cytochem. 46: 41-48 [Abstract] [Full Text]  
• Moll, U.M., Schramm, L.M. (1998). p53--An Acrobat in Tumorigenesis. CROBM 9: 23-37 [Abstract] [Full Text]  
• Jones, B. A., Gores, G. J. (1997). Physiology and pathophysiology of apoptosis in epithelial cells of the liver, pancreas, and intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 273: G1174-G1188 [Abstract] [Full Text]  
• Chin, L., Pomerantz, J., Polsky, D., Jacobson, M., Cohen, C., Cordon-Cardo, C., Horner, J. W. II, DePinho, R. A. (1997). Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev. 11: 2822-2834 [Abstract] [Full Text]  
• Schwartz, R. S. (1997). The Case of the Bare Lymphocyte Syndrome -- Tracking Down Faulty Transcription Factors. NEJM 337: 781-783 [Full Text]  
• Dobashi, K., Sugio, K., Osaki, T., Oka, T., Yasumoto, K. (1997). MICROMETASTATIC P53-POSITIVE CELLS IN THE LYMPH NODES OF NON-SMALL-CELL LUNG CANCER: PROGNOSTIC SIGNIFICANCE. J. Thorac. Cardiovasc. Surg. 114: 339-346 [Abstract] [Full Text]  
• McGill, G., Shimamura, A., Bates, R. C., Savage, R. E., Fisher, D. E. (1997). Loss of Matrix Adhesion Triggers Rapid Transformation-Selective Apoptosis in Fibroblasts. JCB 138: 901-911 [Abstract] [Full Text]  
• Michalides, R. J. A. M., van Veelen, N. M. J., Kristel, P. M. P., Hart, A. A. M., Loftus, B. M., Hilgers, F. J. M., Balm, A. J. M. (1997). Overexpression of Cyclin D1 Indicates a Poor Prognosis in Squamous Cell Carcinoma of the Head and Neck. Arch Otolaryngol Head Neck Surg 123: 497-502 [Abstract]