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Previous Volume 329:1427-1428 November 4, 1993 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Dr. Parrillo (May 20 issue)¹ raises an important issue concerning the use of inhibitors of nitric oxide synthase in septic shock in his article "Pathogenetic Mechanisms of Septic Shock." The view that these inhibitors may be harmful in the treatment of septic shock is based on experiments in animals given 2 to 4 mg of endotoxin per kilogram of body weight. These amounts of endotoxin are 1 million times greater than those that cause cardiovascular changes in humans². In contrast, only concentrations of endotoxin measurable in picograms per milliliter have been detected in the serum of . . . [Full Text of this Article]

References

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• Momin, A. U., Melikian, N., Shah, A. M., Grieve, D. J., Wheatcroft, S. B., John, L., El Gamel, A., Desai, J. B., Nelson, T., Driver, C., Sherwood, R. A., Kearney, M. T. (2006). Leptin is an endothelial-independent vasodilator in humans with coronary artery disease: evidence for tissue specificity of leptin resistance. Eur Heart J 27: 2294-2299 [Abstract] [Full Text]