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Correspondence
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Volume 329:1502-1503 November 11, 1993 Number 20
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Pancreatitis and the Risk of Pancreatic Cancer

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 by Lowenfels, A. B.
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To the Editor: The 14- to 16-fold increase in the risk of pancreatic cancer among patients with chronic pancreatitis, noted by Lowenfels et al. (May 20 issue),1 is striking. However, if the true risk were increased this much, one must wonder why earlier studies did not uncover it.

From the Methods section, it is not clear how the cohort was assembled. The authors mention that recruitment of patients with pancreatitis began in 1946. Does this mean that the protocol and study design were in place in 1946? Or does it mean that the first diagnosis of chronic pancreatitis was retrospectively . . . [Full Text of this Article]

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