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Correspondence
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Volume 329:1740-1741 December 2, 1993 Number 23
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Endothelin Production in Mitral Stenosis

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To the Editor: Endothelin, a newly isolated, endothelium-derived peptide, has contractile and proliferative effects on vascular smooth-muscle cells1,2. Plasma endothelin concentrations are elevated in patients with pulmonary hypertension3. Pulmonary-artery pressure is increased in patients with mitral stenosis. We hypothesized that increased endothelin production in the pulmonary circulation might have a role in the increased vascular tone in this disorder. We therefore measured plasma levels of endothelin-1 in blood from the right atrium and left atrium of 10 patients with mitral stenosis who were undergoing percutaneous mitral valvuloplasty.

The study group consisted of two men and eight women (mean . . . [Full Text of this Article]

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