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Images in Clinical Medicine
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Volume 329:1783 December 9, 1993 Number 24
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Vulvar Herpes Simplex Infection

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Figure 1


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Figure 1. Vulvar Herpes Simplex Infection.

Characteristic histologic changes are seen in herpes simplex virus infection of the vulva. Panel A shows necrosis of the epidermis and dermis, with acute inflammation and nuclear debris on the left, viable mucosal keratinocytes on the right, and multinucleated giant cells in the center (arrow) (hematoxylin-eosin, x90). Panel B shows multinucleated cells with Cowdry type A intranuclear viral inclusions (arrow) (hematoxylin-eosin, x220). Panel C shows nuclear molding (the contours of adjacent nuclei conform to one another) with a ground-glass chromatin pattern (arrow) in an enlarged, multinucleated cell (hematoxylin-eosin, x480). In Panel D, a vaginal . . . [Full Text of this Article]

 



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