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Correspondence
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Volume 329:1896-1898 December 16, 1993 Number 25
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Risk Factors for Hepatocellular Carcinoma in Patients with Chronic Liver Diseases

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 by Tsukuma, H.
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To the Editor: In the report by Tsukuma et al. (June 24 issue)1 on the risk factors for hepatocellular carcinoma in patients with chronic liver disease, the study group was composed of patients with cirrhosis of the liver or chronic hepatitis. It is not stated whether the patients had had liver biopsies, although the criteria for enrollment, "a clinical diagnosis of chronic hepatitis or compensated cirrhosis," suggest that biopsies were not performed in all patients.

I believe that histologic study, particularly in the patients with chronic hepatitis, could have contributed to a more accurate classification of the liver disease. It . . . [Full Text of this Article]

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