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Previous Volume 329:1967-1968 December 23, 1993 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Giaid et al. recently reported (June 17 issue)¹ increased expression of endothelin-1 in vascular endothelial cells of patients with pulmonary hypertension. We have previously reported that patients with pulmonary hypertension have significantly higher plasma endothelin-1 concentrations than healthy controls². Together, these results strongly suggest that the pulmonary production of endothelin-1 may contribute to the vascular abnormalities associated with pulmonary hypertension.

To determine the role of the local production of endothelin-1 in the lungs of patients with pulmonary hypertension, we prospectively studied endothelin-1 concentrations in the lungs of six consecutive patients referred for lung or heart-lung transplantation . . . [Full Text of this Article]

References

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• Eddahibi, S., Morrell, N., d'Ortho, M-P., Naeije, R., Adnot, S. (2002). Pathobiology of pulmonary arterial hypertension. Eur Respir J 20: 1559-1572 [Abstract] [Full Text]  
• Doi, S., Smedira, N., Murray, P. A. (2000). Pulmonary vasoregulation by endothelin in conscious dogs after left lung transplantation. J. Appl. Physiol. 88: 210-218 [Abstract] [Full Text]