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Scientific truths are rarely learned instantaneously except in the movies. Nowhere is this lesson more evident than in Alzheimer's disease. Like many other neuropsychiatric disorders, it has defied attempts to unravel its biologic basis despite increasing public awareness and considerable attention from clinical and basic scientists. In the past few years, research on the proteins found in the brains of victims of Alzheimer's disease has engendered much debate about its pathogenesis and the possibilities for early diagnosis and treatment. Since 1991, when a team of British and American scientists reported their discovery of a defect in the beta-amyloid protein precursor
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