The discovery that mammalian cells generate nitric oxide, agas previously considered to be merely an atmospheric pollutant,is providing important information about many biologic processes.Nitric oxide is synthesized from the amino acid L-arginine bya family of enzymes, the nitric oxide synthases, through a hithertounrecognized metabolic route -- namely, the L-arginine-nitricoxide pathway1,2,3,4,5,6,7,8.
The synthesis of nitric oxide by vascular endothelium is responsiblefor the vasodilator tone that is essential for the regulationof blood pressure. In the central nervous system nitric oxideis a neurotransmitter that underpins several functions, includingthe formation of memory. In . . . [Full Text of this Article]
Nitric Oxide in the Cardiovascular and Pulmonary Systems
Physiologic Roles
Clinical Implications
Pathologic Release of Nitric Oxide
The Nervous System
Central Nervous System
Physiologic Roles
Pathologic Roles
Peripheral Nervous System
Nitric Oxide as a Cytostatic and Cytotoxic Agent
Macrophages and Neutrophils
Role of Nitric Oxide in Immunity and Inflammation
Regulation of Nitric Oxide Synthase Activity
Metabolism of Nitric Oxide
Conclusions
Source Information
From Wellcome Research Laboratories, Langley Ct., S. Eden Park Rd., Beckenham, Kent BR3 3BS, United Kingdom, where reprint requests should be addressed to Dr. Moncada.
Kris-Etherton, P. M., Hu, F. B., Ros, E., Sabate, J.
(2008). The Role of Tree Nuts and Peanuts in the Prevention of Coronary Heart Disease: Multiple Potential Mechanisms. J. Nutr.
138: 1746S-1751S
[Abstract][Full Text]
Kawakami, A., Osaka, M., Tani, M., Azuma, H., Sacks, F. M., Shimokado, K., Yoshida, M.
(2008). Apolipoprotein CIII Links Hyperlipidemia With Vascular Endothelial Cell Dysfunction. Circulation
118: 731-742
[Abstract][Full Text]
Nadeem, A., Masood, A., Siddiqui, N.
(2008). Review: Oxidant--antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options. Therapeutic Advances in Respiratory Disease
2: 215-235
[Abstract]
Lundberg, J. O., Weitzberg, E.
(2008). Nitrite reduction to nitric oxide in the vasculature. Am. J. Physiol. Heart Circ. Physiol.
295: H477-H478
[Full Text]
Peyter, A.-C., Muehlethaler, V., Liaudet, L., Marino, M., Di Bernardo, S., Diaceri, G., Tolsa, J.-F.
(2008). Muscarinic receptor M1 and phosphodiesterase 1 are key determinants in pulmonary vascular dysfunction following perinatal hypoxia in mice. Am. J. Physiol. Lung Cell. Mol. Physiol.
295: L201-L213
[Abstract][Full Text]
Gray, C. L., Ndefo, U. A.
(2008). Nebivolol: A new antihypertensive agent. Am J Health Syst Pharm
65: 1125-1133
[Abstract][Full Text]
Yin, D., Wang, X., Konda, B. M., Ong, J. M., Hu, J., Sacapano, M. R., Ko, M. K., Espinoza, A. J., Irvin, D. K., Shu, Y., Black, K. L.
(2008). Increase in Brain Tumor Permeability in Glioma-Bearing Rats with Nitric Oxide Donors. Clin. Cancer Res.
14: 4002-4009
[Abstract][Full Text]
Dietze, G. J, Henriksen, E. J
(2008). Review: Angiotensin-converting enzyme in skeletal muscle: sentinel of blood pressure control and glucose homeostasis. Journal of Renin-Angiotensin-Aldosterone System
9: 75-88
[Abstract]
Lim, K. G., Mottram, C.
(2008). The Use of Fraction of Exhaled Nitric Oxide in Pulmonary Practice. Chest
133: 1232-1242
[Abstract][Full Text]
Zhao, Y., Zhang, J., Li, H., Li, Y., Ren, J., Luo, M., Zheng, X.
(2008). An NADPH Sensor Protein (HSCARG) Down-regulates Nitric Oxide Synthesis by Association with Argininosuccinate Synthetase and Is Essential for Epithelial Cell Viability. J. Biol. Chem.
283: 11004-11013
[Abstract][Full Text]
Katayama, N., Nakajou, K., Komori, H., Uchida, K., Yokoe, J.-i., Yasui, N., Yamamoto, H., Kai, T., Sato, M., Nakagawa, T., Takeya, M., Maruyama, T., Otagiri, M.
(2008). Design and Evaluation of S-Nitrosylated Human Serum Albumin as a Novel Anticancer Drug. J. Pharmacol. Exp. Ther.
325: 69-76
[Abstract][Full Text]
Grande, L. A., Loeser, J. D., Samii, A.
(2008). Recurrent Transient Global Amnesia with Intrathecal Baclofen. Anesth. Analg.
106: 1284-1287
[Abstract][Full Text]
Koyner, J. L., Murray, P. T.
(2008). Mechanical Ventilation and Lung-Kidney Interactions. CJASN
3: 562-570
[Full Text]
Liu, V. W.T., Huang, P. L.
(2008). Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice. Cardiovasc Res
77: 19-29
[Abstract][Full Text]
Morris, C. R., Suh, J. H., Hagar, W., Larkin, S., Bland, D. A., Steinberg, M. H., Vichinsky, E. P., Shigenaga, M., Ames, B., Kuypers, F. A., Klings, E. S.
(2008). Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease. Blood
111: 402-410
[Abstract][Full Text]
Worthley, M. I., Kanani, R. S., Sun, Y.-H., Sun, Y., Goodhart, D. M., Curtis, M. J., Anderson, T. J.
(2007). Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries. Cardiovasc Res
76: 539-546
[Abstract][Full Text]
Mercuro, G., Saiu, F., Deidda, M., Mercuro, S., Vitale, C., Rosano, G. M. C.
(2007). Effect of Hormone Therapy on Exercise Capacity in Early Postmenopausal Women. Obstet Gynecol
110: 780-787
[Abstract][Full Text]
Niedbala, W., Cai, B., Liu, H., Pitman, N., Chang, L., Liew, F. Y.
(2007). Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc. Natl. Acad. Sci. USA
104: 15478-15483
[Abstract][Full Text]
Hong, C.-C., Ambrosone, C. B., Ahn, J., Choi, J.-Y., McCullough, M. L., Stevens, V. L., Rodriguez, C., Thun, M. J., Calle, E. E.
(2007). Genetic Variability in Iron-Related Oxidative Stress Pathways (Nrf2, NQ01, NOS3, and HO-1), Iron Intake, and Risk of Postmenopausal Breast Cancer. Cancer Epidemiol. Biomarkers Prev.
16: 1784-1794
[Abstract][Full Text]
Tessari, P., Coracina, A., Puricelli, L., Vettore, M., Cosma, A., Millioni, R., Cecchet, D., Avogaro, A., Tiengo, A., Kiwanuka, E.
(2007). Acute effect of insulin on nitric oxide synthesis in humans: a precursor-product isotopic study. Am. J. Physiol. Endocrinol. Metab.
293: E776-E782
[Abstract][Full Text]
Liu, Z., Jiang, Y., Hao, H., Gupta, K., Xu, J., Chu, L., McFalls, E., Zweier, J., Verfaillie, C., Bache, R. J.
(2007). Endothelial nitric oxide synthase is dynamically expressed during bone marrow stem cell differentiation into endothelial cells. Am. J. Physiol. Heart Circ. Physiol.
293: H1760-H1765
[Abstract][Full Text]
Barr, F. E., Tirona, R. G., Taylor, M. B., Rice, G., Arnold, J., Cunningham, G., Smith, H. A.B., Campbell, A., Canter, J. A., Christian, K. G., Drinkwater, D. C., Scholl, F., Kavanaugh-McHugh, A., Summar, M. L.
(2007). Pharmacokinetics and safety of intravenously administered citrulline in children undergoing congenital heart surgery: Potential therapy for postoperative pulmonary hypertension. J. Thorac. Cardiovasc. Surg.
134: 319-326
[Abstract][Full Text]
Engeli, S., Boschmann, M., Adams, F., Franke, G., Gorzelniak, K., Janke, J., Luft, F. C., Jordan, J.
(2007). Dissociation between Adipose Nitric Oxide Synthase Expression and Tissue Metabolism. J. Clin. Endocrinol. Metab.
92: 2706-2711
[Abstract][Full Text]
Boger, R. H.
(2007). The Pharmacodynamics of L-Arginine. J. Nutr.
137: 1650S-1655S
[Abstract][Full Text]
Tanaka, Y., Hayashi, T., Kitajima, H., Sumi, K., Fujimura, M.
(2007). Inhaled Nitric Oxide Therapy Decreases the Risk of Cerebral Palsy in Preterm Infants With Persistent Pulmonary Hypertension of the Newborn. Pediatrics
119: 1159-1164
[Abstract][Full Text]
Jaumdally, R., Varma, C., Macfadyen, R. J., Lip, G. Y.H.
(2007). Coronary sinus blood sampling: an insight into local cardiac pathophysiology and treatment?. Eur Heart J
28: 929-940
[Abstract][Full Text]
Andreozzi, F., Laratta, E., Procopio, C., Hribal, M. L., Sciacqua, A., Perticone, M., Miele, C., Perticone, F., Sesti, G.
(2007). Interleukin-6 Impairs the Insulin Signaling Pathway, Promoting Production of Nitric Oxide in Human Umbilical Vein Endothelial Cells. Mol. Cell. Biol.
27: 2372-2383
[Abstract][Full Text]
Ishima, Y., Sawa, T., Kragh-Hansen, U., Miyamoto, Y., Matsushita, S., Akaike, T., Otagiri, M.
(2007). S-Nitrosylation of Human Variant Albumin Liprizzi (R410C) Confers Potent Antibacterial and Cytoprotective Properties. J. Pharmacol. Exp. Ther.
320: 969-977
[Abstract][Full Text]
Isenberg, J. S., Hyodo, F., Matsumoto, K.-I., Romeo, M. J., Abu-Asab, M., Tsokos, M., Kuppusamy, P., Wink, D. A., Krishna, M. C., Roberts, D. D.
(2007). Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation. Blood
109: 1945-1952
[Abstract][Full Text]
Mohammed, K. A., Nasreen, N., Tepper, R. S., Antony, V. B.
(2007). Cyclic stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide release. Am. J. Physiol. Lung Cell. Mol. Physiol.
292: L559-L566
[Abstract][Full Text]
Shimasaki, Y., Saito, Y., Yoshimura, M., Kamitani, S., Miyamoto, Y., Masuda, I., Nakayama, M., Mizuno, Y., Ogawa, H., Yasue, H., Nakao, K.
(2007). The Effects of Long-term Smoking on Endothelial Nitric Oxide Synthase mRNA Expression in Human Platelets as Detected With Real-time Quantitative RT-PCR. CLIN APPL THROMB HEMOST
13: 43-51
[Abstract]
Orozco, A. V., Sosa, Z., Fillipa, V., Mohamed, F., Rastrilla, A. M.
(2006). The cholinergic influence on the mesenteric ganglion affects the liberation of ovarian steroids and nitric oxide in oestrus day rats: characterization of an ex vivo system. J Endocrinol
191: 587-598
[Abstract][Full Text]
Casas, J. P., Cavalleri, G. L., Bautista, L. E., Smeeth, L., Humphries, S. E., Hingorani, A. D.
(2006). Endothelial Nitric Oxide Synthase Gene Polymorphisms and Cardiovascular Disease: A HuGE Review. Am J Epidemiol
164: 921-935
[Abstract][Full Text]
Panda, S. P., Gao, Y. T., Roman, L. J., Martasek, P., Salerno, J. C., Masters, B. S. S.
(2006). The Role of a Conserved Serine Residue within Hydrogen Bonding Distance of FAD in Redox Properties and the Modulation of Catalysis by Ca2+/Calmodulin of Constitutive Nitric-oxide Synthases. J. Biol. Chem.
281: 34246-34257
[Abstract][Full Text]
Cuenca, J., Martin-Sanz, P., Alvarez-Barrientos, A. M., Bosca, L., Goren, N.
(2006). Infiltration of Inflammatory Cells Plays an Important Role in Matrix Metalloproteinase Expression and Activation in the Heart during Sepsis. Am. J. Pathol.
169: 1567-1576
[Abstract][Full Text]
Mittermayer, F., Krzyzanowska, K., Exner, M., Mlekusch, W., Amighi, J., Sabeti, S., Minar, E., Muller, M., Wolzt, M., Schillinger, M.
(2006). Asymmetric Dimethylarginine Predicts Major Adverse Cardiovascular Events in Patients With Advanced Peripheral Artery Disease. Arterioscler. Thromb. Vasc. Bio.
26: 2536-2540
[Abstract][Full Text]
Guo, X., Oldham, M. J., Kleinman, M. T., Phalen, R. F., Kassab, G. S.
(2006). Effect of cigarette smoking on nitric oxide, structural, and mechanical properties of mouse arteries. Am. J. Physiol. Heart Circ. Physiol.
291: H2354-H2361
[Abstract][Full Text]
Stork, C. J., Li, Y. V.
(2006). Intracellular Zinc Elevation Measured with a "Calcium-Specific" Indicator during Ischemia and Reperfusion in Rat Hippocampus: A Question on Calcium Overload. J. Neurosci.
26: 10430-10437
[Abstract][Full Text]
Zimmet, J. M., Hare, J. M.
(2006). Nitroso-Redox Interactions in the Cardiovascular System. Circulation
114: 1531-1544
[Full Text]
Tsuruoka, S., Watanabe, S., Purkerson, J. M., Fujimura, A., Schwartz, G. J.
(2006). Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosis. Am. J. Physiol. Renal Physiol.
291: F866-F873
[Abstract][Full Text]
Fang, Y., Mu, J.-J., He, L.-C., Wang, S.-C., Liu, Z.-Q.
(2006). Salt Loading on Plasma Asymmetrical Dimethylarginine and the Protective Role of Potassium Supplement in Normotensive Salt-Sensitive Asians. Hypertension
48: 724-729
[Abstract][Full Text]
Broderick, K. E., Feala, J., McCulloch, A., Paternostro, G., Sharma, V. S., Pilz, R. B., Boss, G. R.
(2006). The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis. FASEB J.
20: 1865-1873
[Abstract][Full Text]
Kalea, A. Z., Schuschke, D. A., Harris, P. D., Klimis-Zacas, D. J.
(2006). Cyclo-Oxygenase Inhibition Restores the Attenuated Vasodilation in Manganese-Deficient Rat Aorta. J. Nutr.
136: 2302-2307
[Abstract][Full Text]
Su, W.-W., Cheng, S.-T., Hsu, T.-S., Ho, W.-J.
(2006). Abnormal flow-mediated vasodilation in normal-tension glaucoma using a noninvasive determination for peripheral endothelial dysfunction.. IOVS
47: 3390-3394
[Abstract][Full Text]
Hayashi, T., Esaki, T., Sumi, D., Mukherjee, T., Iguchi, A., Chaudhuri, G.
(2006). Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism. Proc. Natl. Acad. Sci. USA
103: 10485-10490
[Abstract][Full Text]
Ramzy, D., Rao, V., Tumiati, L. C., Xu, N., Sheshgiri, R., Miriuka, S., Delgado, D. H., Ross, H. J.
(2006). Elevated Endothelin-1 Levels Impair Nitric Oxide Homeostasis Through a PKC-Dependent Pathway. Circulation
114: I-319-I-326
[Abstract][Full Text]
Smith, H. A.B., Canter, J. A., Christian, K. G., Drinkwater, D. C., Scholl, F. G., Christman, B. W., Rice, G. D., Barr, F. E., Summar, M. L.
(2006). Nitric oxide precursors and congenital heart surgery: A randomized controlled trial of oral citrulline. J. Thorac. Cardiovasc. Surg.
132: 58-65
[Abstract][Full Text]
Nakano, D., Kwak, C.-J., Fujii, K., Ikemura, K., Satake, A., Ohkita, M., Takaoka, M., Ono, Y., Nakai, M., Tomimori, N., Kiso, Y., Matsumura, Y.
(2006). Sesamin Metabolites Induce an Endothelial Nitric Oxide-Dependent Vasorelaxation through Their Antioxidative Property-Independent Mechanisms: Possible Involvement of the Metabolites in the Antihypertensive Effect of Sesamin. J. Pharmacol. Exp. Ther.
318: 328-335
[Abstract][Full Text]
Zhang, C., Lopez-Ridaura, R., Hunter, D. J., Rifai, N., Hu, F. B.
(2006). Common variants of the endothelial nitric oxide synthase gene and the risk of coronary heart disease among u.s. Diabetic men.. Diabetes
55: 2140-2147
[Abstract][Full Text]
Veverka, A., Nuzum, D. S, Jolly, J. L
(2006). Nebivolol: A Third-Generation {beta}-Adrenergic Blocker. The Annals of Pharmacotherapy
40: 1353-1360
[Abstract][Full Text]
Mineo, C., Deguchi, H., Griffin, J. H., Shaul, P. W.
(2006). Endothelial and Antithrombotic Actions of HDL. Circ. Res.
98: 1352-1364
[Abstract][Full Text]
Zaedi, S., Jesmin, S., Maeda, S., Shimojo, N., Yamaguchi, I., Goto, K., Miyauchi, T.
(2006). Alterations in Gene Expressions Encoding PreproET-1 and NOS in Pulmonary Tissue in Endotoxemic Rats.. Exp. Biol. Med.
231: 992-996
[Abstract][Full Text]
Linscheid, P., Seboek, D., Zulewski, H., Scherberich, A., Blau, N., Keller, U., Muller, B.
(2006). Cytokine-induced metabolic effects in human adipocytes are independent of endogenous nitric oxide. Am. J. Physiol. Endocrinol. Metab.
290: E1068-E1077
[Abstract][Full Text]
Sidell, B. D., O'Brien, K. M.
(2006). When bad things happen to good fish: the loss of hemoglobin and myoglobin expression in Antarctic icefishes. J. Exp. Biol.
209: 1791-1802
[Abstract][Full Text]
Datta, P. K., Sharma, M., Duann, P., Lianos, E. A.
(2006). Effect of Nitric Oxide Synthase Inhibition on Proteinuria in Glomerular Immune Injury.. Exp. Biol. Med.
231: 576-584
[Abstract][Full Text]
Kim, H. J., Tsoy, I., Park, M. K., Lee, Y. S., Lee, J. H., Seo, H. G., Chang, K. C.
(2006). Iron Released by Sodium Nitroprusside Contributes to Heme Oxygenase-1 Induction via the cAMP-Protein Kinase A-Mitogen-Activated Protein Kinase Pathway in RAW 264.7 Cells. Mol. Pharmacol.
69: 1633-1640
[Abstract][Full Text]
Hataishi, R., Rodrigues, A. C., Morgan, J. G., Ichinose, F., Derumeaux, G., Bloch, K. D., Picard, M. H., Scherrer-Crosbie, M.
(2006). Nitric oxide synthase 2 and pressure-overload-induced left ventricular remodelling in mice. Exp Physiol
91: 633-639
[Abstract][Full Text]
Guo, X., Lu, X., Ren, H., Levin, E. R., Kassab, G. S.
(2006). Estrogen modulates the mechanical homeostasis of mouse arterial vessels through nitric oxide. Am. J. Physiol. Heart Circ. Physiol.
290: H1788-H1797
[Abstract][Full Text]
Choi, J., Hoffman, L. A., Rodway, G. W., Sethi, J. M.
(2006). Markers of lung disease in exhaled breath: nitric oxide.. Biol Res Nurs
7: 241-255
[Abstract]
Chiossi, G., Verocchi, G., Venturini, P., Facchinetti, F.
(2006). Changes in Cervical Nitric Oxide Concentration Correlate With Bishop Score and Cervical Length Modifications in Prostaglandin E2-Mediated Induction of Labor. Reproductive Sciences
13: 203-208
[Abstract]
Mineo, C., Shaul, P. W.
(2006). Circulating cardiovascular disease risk factors and signaling in endothelial cell caveolae. Cardiovasc Res
70: 31-41
[Abstract][Full Text]
Morihara, N., Sumioka, I., Ide, N., Moriguchi, T., Uda, N., Kyo, E.
(2006). Aged Garlic Extract Maintains Cardiovascular Homeostasis in Mice and Rats. J. Nutr.
136: 777S-781S
[Abstract][Full Text]
Nakamura, Y., Yasuoka, H., Tsujimoto, M., Yoshidome, K., Nakahara, M., Nakao, K., Nakamura, M., Kakudo, K.
(2006). Nitric Oxide in Breast Cancer: Induction of Vascular Endothelial Growth Factor-C and Correlation with Metastasis and Poor Prognosis. Clin. Cancer Res.
12: 1201-1207
[Abstract][Full Text]
Mason, M. G., Nicholls, P., Wilson, M. T., Cooper, C. E.
(2006). Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase. Proc. Natl. Acad. Sci. USA
103: 708-713
[Abstract][Full Text]
Elliott, P., Stamler, J., Dyer, A. R., Appel, L., Dennis, B., Kesteloot, H., Ueshima, H., Okayama, A., Chan, Q., Garside, D. B., Zhou, B., for the INTERMAP Cooperative Research Group,
(2006). Association Between Protein Intake and Blood Pressure: The INTERMAP Study. Arch Intern Med
166: 79-87
[Abstract][Full Text]
Schulman, S. P., Becker, L. C., Kass, D. A., Champion, H. C., Terrin, M. L., Forman, S., Ernst, K. V., Kelemen, M. D., Townsend, S. N., Capriotti, A., Hare, J. M., Gerstenblith, G.
(2006). L-Arginine Therapy in Acute Myocardial Infarction: The Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) Randomized Clinical Trial. JAMA
295: 58-64
[Abstract][Full Text]
Kerkeni, M., Addad, F., Chauffert, M., Myara, A., Ben Farhat, M., Miled, A., Maaroufi, K., Trivin, F.
(2006). Hyperhomocysteinemia, Endothelial Nitric Oxide Synthase Polymorphism, and Risk of Coronary Artery Disease. Clin. Chem.
52: 53-58
[Abstract][Full Text]
Liu, Y.-H., Carretero, O. A., Cingolani, O. H., Liao, T.-D., Sun, Y., Xu, J., Li, L. Y., Pagano, P. J., Yang, J. J., Yang, X.-P.
(2005). Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction. Am. J. Physiol. Heart Circ. Physiol.
289: H2616-H2623
[Abstract][Full Text]
Galie, N., Ghofrani, H. A., Torbicki, A., Barst, R. J., Rubin, L. J., Badesch, D., Fleming, T., Parpia, T., Burgess, G., Branzi, A., Grimminger, F., Kurzyna, M., Simonneau, G., the Sildenafil Use in Pulmonary Arterial Hypertens,
(2005). Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension. NEJM
353: 2148-2157
[Abstract][Full Text]
Hoit, B. D., Dalton, N. D., Erzurum, S. C., Laskowski, D., Strohl, K. P., Beall, C. M.
(2005). Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders. J. Appl. Physiol.
99: 1796-1801
[Abstract][Full Text]
Razmara, A., Krause, D. N., Duckles, S. P.
(2005). Testosterone augments endotoxin-mediated cerebrovascular inflammation in male rats. Am. J. Physiol. Heart Circ. Physiol.
289: H1843-H1850
[Abstract][Full Text]
Sato, M., Hida, N., Umezawa, Y.
(2005). Imaging the nanomolar range of nitric oxide with an amplifier-coupled fluorescent indicator in living cells. Proc. Natl. Acad. Sci. USA
102: 14515-14520
[Abstract][Full Text]
Fatini, C., Mannini, L., Sticchi, E., Cecchi, E., Bruschettini, A., Leprini, E., Pagnini, P., Gensini, G. F., Prisco, D., Abbate, R.
(2005). eNOS Gene Affects Red Cell Deformability: Role of T-786C, G894T, and 4a/4b Polymorphisms. CLIN APPL THROMB HEMOST
11: 481-488
[Abstract]
Page, A., Reich, H., Zhou, J., Lai, V., Cattran, D. C., Scholey, J. W., Miller, J. A.
(2005). Endothelial Nitric Oxide Synthase Gene/Gender Interactions and the Renal Hemodynamic Response to Angiotensin II. J. Am. Soc. Nephrol.
16: 3053-3060
[Abstract][Full Text]
Fratelli, M., Goodwin, L. O., Orom, U. A., Lombardi, S., Tonelli, R., Mengozzi, M., Ghezzi, P.
(2005). Gene expression profiling reveals a signaling role of glutathione in redox regulation. Proc. Natl. Acad. Sci. USA
102: 13998-14003
[Abstract][Full Text]
Monraats, P. S., Rana, J. S., Nierman, M. C., Pires, N. M.M., Zwinderman, A. H., Kastelein, J. J.P., Kuivenhoven, J. A., de Maat, M. P.M., Rittersma, S. Z.H., Schepers, A., Doevendans, P. A.F., de Winter, R. J., Tio, R. A., Frants, R. R., Quax, P. H.A., van Der Laarse, A., van Der Wall, E. E., Jukema, J. W.
(2005). Lipoprotein Lipase Gene Polymorphisms and the Risk of Target Vessel Revascularization After Percutaneous Coronary Intervention. J Am Coll Cardiol
46: 1093-1100
[Abstract][Full Text]
Masri, F. A., Comhair, S. A. A., Koeck, T., Xu, W., Janocha, A., Ghosh, S., Dweik, R. A., Golish, J., Kinter, M., Stuehr, D. J., Erzurum, S. C., Aulak, K. S.
(2005). Abnormalities in Nitric Oxide and Its Derivatives in Lung Cancer. Am. J. Respir. Crit. Care Med.
172: 597-605
[Abstract][Full Text]
Peng, X., Abdulnour, R.-E. E., Sammani, S., Ma, S.-F., Han, E. J., Hasan, E. J., Tuder, R., Garcia, J. G. N., Hassoun, P. M.
(2005). Inducible Nitric Oxide Synthase Contributes to Ventilator-induced Lung Injury. Am. J. Respir. Crit. Care Med.
172: 470-479
[Abstract][Full Text]
Esposito, E., Iacono, A., Raso, G. M., Pacilio, M., Coppola, A., Di Carlo, R., Meli, R.
(2005). Raloxifene, a Selective Estrogen Receptor Modulator, Reduces Carrageenan-Induced Acute Inflammation in Normal and Ovariectomized Rats. Endocrinology
146: 3301-3308
[Abstract][Full Text]
He, J., Gu, D., Wu, X., Chen, J., Duan, X., Chen, J., Whelton, P. K.
(2005). Effect of Soybean Protein on Blood Pressure: A Randomized, Controlled Trial. ANN INTERN MED
143: 1-9
[Abstract][Full Text]
Jessen, N., Goodyear, L. J.
(2005). Contraction signaling to glucose transport in skeletal muscle. J. Appl. Physiol.
99: 330-337
[Abstract][Full Text]
Ratnawati, R, Thomas, P S
(2005). Exhaled nitric oxide in paediatric asthma. Chronic Respiratory Disease
2: 163-174
[Abstract]
Maas, R.
(2005). Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA). Vasc Med
10: S49-S57
[Abstract]
Fatini, C., Sofi, F., Gori, A. M., Sticchi, E., Marcucci, R., Lenti, M., Casini, A., Surrenti, C., Abbate, R., Gensini, G. F.
(2005). Endothelial Nitric Oxide Synthase -786T>C, but Not 894G>T and 4a4b, Polymorphism Influences Plasma Homocysteine Concentrations in Persons with Normal Vitamin Status. Clin. Chem.
51: 1159-1164
[Abstract][Full Text]
Carrasco-Martin, C., Alonso-Orgaz, S., De la Pinta, J. C, Marques, M., Macaya, C., Barrientos, A., Gonzalez, M. M, Garcia-Mendez, A., Mateos-Caceres, P. J., Porres, J. C, Rico, L. A, Lopez-Farre, A. J
(2005). Endothelial hypoxic preconditioning in rat hypoxic isolated aortic segments. Exp Physiol
90: 557-569
[Abstract][Full Text]
Harel, F., Dupuis, J., Benelfassi, A., Ruel, N., Gregoire, J.
(2005). Radionuclide plethysmography for noninvasive evaluation of peripheral arterial blood flow. Am. J. Physiol. Heart Circ. Physiol.
289: H258-H262
[Abstract][Full Text]
Arenas, I. A., Armstrong, S. J., Xu, Y., Davidge, S. T.
(2005). Chronic Tumor Necrosis Factor-{alpha} Inhibition Enhances NO Modulation of Vascular Function in Estrogen-Deficient Rats. Hypertension
46: 76-81
[Abstract][Full Text]
Kristjansson, G, Hogman, M, Venge, P, Hallgren, R
(2005). Gut mucosal granulocyte activation precedes nitric oxide production: studies in coeliac patients challenged with gluten and corn. Gut
54: 769-774
[Abstract][Full Text]
Maas, R.
(2005). Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA). Vasc Med
10: S49-S57
[Abstract]
Szmitko, P. E., Verma, S.
(2005). Antiatherogenic potential of red wine: clinician update. Am. J. Physiol. Heart Circ. Physiol.
288: H2023-H2030
[Abstract][Full Text]
Tousoulis, D, Antoniades, C, Stefanadis, C
(2005). Evaluating endothelial function in humans: a guide to invasive and non-invasive techniques. Heart
91: 553-558
[Full Text]
Broderick, K. E., Singh, V., Zhuang, S., Kambo, A., Chen, J. C., Sharma, V. S., Pilz, R. B., Boss, G. R.
(2005). Nitric Oxide Scavenging by the Cobalamin Precursor Cobinamide. J. Biol. Chem.
280: 8678-8685
[Abstract][Full Text]
Virdis, A., Colucci, R., Fornai, M., Blandizzi, C., Duranti, E., Pinto, S., Bernardini, N., Segnani, C., Antonioli, L., Taddei, S., Salvetti, A., Del Tacca, M.
(2005). Cyclooxygenase-2 Inhibition Improves Vascular Endothelial Dysfunction in a Rat Model of Endotoxic Shock: Role of Inducible Nitric-Oxide Synthase and Oxidative Stress. J. Pharmacol. Exp. Ther.
312: 945-953
[Abstract][Full Text]
Cakir, E., Ozcan, O., Yaman, H., Akgul, E. O., Bilgi, C., Erbil, M. K., Yesilova, Z.
(2005). Elevated Plasma Concentration of Asymmetric Dimethylarginine That Is Reduced by Single Dose Testosterone Administration in Idiopathic Hypogonadotropic Hypogonadism Patients. J. Clin. Endocrinol. Metab.
90: 1651-1654
[Abstract][Full Text]
Ojoo, J C, Mulrennan, S A, Kastelik, J A, Morice, A H, Redington, A E
(2005). Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis. Thorax
60: 22-26
[Abstract][Full Text]
Shaamash, A.H., Zakhari, M.M.
(2005). Increased serum levels of nitric oxide metabolites among users: a possible role in progestin-induced bleeding. Hum Reprod
20: 302-306
[Abstract][Full Text]
Luiking, Y. C., Poeze, M., Ramsay, G., Deutz, N. E. P.
(2005). The Role of Arginine in Infection and Sepsis. JPEN J Parenter Enteral Nutr
29: S70-S74
[Abstract][Full Text]
Powell, L. A, Warpeha, K. M, Xu, W., Walker, B., Trimble, E. R
(2004). High glucose decreases intracellular glutathione concentrations and upregulates inducible nitric oxide synthase gene expression in intestinal epithelial cells. J Mol Endocrinol
33: 797-803
[Abstract][Full Text]
Previous
