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Previous Volume 329:2028-2029 December 30, 1993 Number 27 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The syndrome of familial adenomatous polyposis is characterized by the emergence of multiple (>100) colonic polyps early in life and by inevitable progression to colonic carcinoma. The gene responsible for this syndrome, the adenomatous polyposis coli (APC) gene, is localized on chromosome 5q21 and encodes for a 300-kd protein whose function is still unknown. On the basis of standard genetic techniques, two thirds of patients with familial adenomatous polyposis have mutations in the APC gene; however, the approaches currently used to identify these genetic lesions have been sufficiently cumbersome and insensitive to preclude their common use in clinical laboratories. This . . . [Full Text of this Article]

References

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