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Previous Volume 329:168-171 July 15, 1993 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Human herpesvirus 6 (HHV-6) was first isolated from patients with the acquired immunodeficiency syndrome or lymphoproliferative diseases and was named human B-lymphotropic virus¹. However, later studies revealed that the virus is T-lymphotropic in vitro² and in vivo³. Recently, two genotypes of HHV-6 (type A and type B) have been distinguished on the basis of their restriction polymorphism^4,5,6. HHV-6 has been identified as the etiologic agent of exanthem subitum in infants,⁷ and an acute febrile illness in young children⁸. Most people are seropositive for HHV-6 by the age of three years^9,10.

HHV-6 also produces latent or . . . [Full Text of this Article]

Case Report

Methods

Phenotypic Analysis of Atypical Lymphocytes

Immunohistochemical Staining

Examination of Viral Antigen

Titration of Anti-HHV-6 Antibody

Examination of Herpesvirus DNA by the Polymerase Chain Reaction

Genotyping of HHV-6

Results

Discussion

Source Information

From the Departments of Hematology (K.A.) and Dermatology (S.H.), Harasanshin General Hospital, Fukuoka, Japan; the Department of Microbiology, Miyazaki Medical College, Miyazaki, Japan (Y.E., T.M., Y.M.); the First Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan (Y.S., M.K.); and the First Department of Internal Medicine, Kyushu University, Fukuoka, Japan (M.H., Y.N.).

Address reprint requests to Dr. Akashi at the Department of Hematology, Harasanshin General Hospital, 1-8 Taihaku-machi, Hakata-ku, Fukuoka 812, Japan.

References

Related Letters:

Primary Human Herpesvirus 6 Infection in an Adult
Morris D. J., Appleton A. L., Sviland L., Schmidt C.A., Wilborn F.F., Siegert W., Cone R., Corey L., Hackman R., Akashi K., Eizuru Y., Sumiyoshi Y.
Extract | Full Text  
N Engl J Med 1993; 329:1817-1819, Dec 9, 1993. Correspondence

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