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Original Article
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Volume 329:172-175 July 15, 1993 Number 3
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A Single Neoplastic Clone in Sequential Biopsy Specimens from a Patient with Primary Gastric-Mucosa-Associated Lymphoid-Tissue Lymphoma and Sjogren's Syndrome
Timothy C. Diss, Huaizheng Peng, Andrew C. Wotherspoon, Langxing Pan, Paul M. Speight, and Peter G. Isaacson

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Low-grade B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) that occur in the stomach, small intestine, salivary gland, lung, and thyroid are indolent neoplasms characterized by a prolonged clinical course and persistent disease at the site of origin1. The mechanism by which the neoplastic cells remain committed to a single site, the presence or absence of neoplastic-cell traffic or homing, and the specific dissemination of MALT lymphomas to other mucosal sites2 are all properties of these lymphomas that are poorly understood. Investigation of these features has been hampered by the absence of a tumor-cell-specific marker with which to examine the . . . [Full Text of this Article]

Case Report

Methods

Immunohistochemical Analysis

PCR Analysis

Cloning and Sequencing

Results

Discussion


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From the Department of Histopathology, University College London Medical School (T.C.D., H.P., A.C.W., L.P., P.G.I.), and the Department of Oral Pathology, Institute of Dental Surgery, Eastman Dental Hospital (P.M.S.), both in London.

Address reprint requests to Professor Isaacson at the Department of Histopathology, University College London Medical School, University St., London WC1E 6JJ, United Kingdom.

References


Related Letters:

Mucosa-Associated Lymphoid-Tissue Lymphoma
Zelenetz A. D., Diss T.C., Pan L.X., Isaacson P.G.
Extract | Full Text  
N Engl J Med 1993; 329:1657, Nov 25, 1993. Correspondence

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