A Single Neoplastic Clone in Sequential Biopsy Specimens from a Patient with Primary Gastric-Mucosa-Associated Lymphoid-Tissue Lymphoma and Sjogren's Syndrome
Timothy C. Diss, Huaizheng Peng, Andrew C. Wotherspoon, Langxing Pan, Paul M. Speight, and Peter G. Isaacson
Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
Low-grade B-cell lymphomas of mucosa-associated lymphoid tissue(MALT) that occur in the stomach, small intestine, salivarygland, lung, and thyroid are indolent neoplasms characterizedby a prolonged clinical course and persistent disease at thesite of origin1. The mechanism by which the neoplastic cellsremain committed to a single site, the presence or absence ofneoplastic-cell traffic or homing, and the specific disseminationof MALT lymphomas to other mucosal sites2 are all propertiesof these lymphomas that are poorly understood. Investigationof these features has been hampered by the absence of a tumor-cell-specificmarker with which to examine the . . . [Full Text of this Article]
Case Report
Methods
Immunohistochemical Analysis
PCR Analysis
Cloning and Sequencing
Results
Discussion
Source Information
From the Department of Histopathology, University College London Medical School (T.C.D., H.P., A.C.W., L.P., P.G.I.), and the Department of Oral Pathology, Institute of Dental Surgery, Eastman Dental Hospital (P.M.S.), both in London.
Address reprint requests to Professor Isaacson at the Department of Histopathology, University College London Medical School, University St., London WC1E 6JJ, United Kingdom.
Morgan, J. A., Yin, Y., Borowsky, A. D., Kuo, F., Nourmand, N., Koontz, J. I., Reynolds, C., Soreng, L., Griffin, C. A., Graeme-Cook, F., Harris, N. L., Weisenburger, D., Pinkus, G. S., Fletcher, J. A., Sklar, J.
(1999). Breakpoints of the t(11;18)(q21;q21) in Mucosa-associated Lymphoid Tissue (MALT) Lymphoma Lie within or near the Previously Undescribed Gene MALT1 in Chromosome 18. Cancer Res.
59: 6205-6213
[Abstract][Full Text]
Jennings, C. D., Foon, K. A.
(1997). Recent Advances in Flow Cytometry: Application to the Diagnosis of Hematologic Malignancy. Blood
90: 2863-2892
[Full Text]
Royer, B., Cazals-Hatem, D., Sibilia, J., Agbalika, F., Cayuela, J.-M., Soussi, T., Maloisel, F., Clauvel, J.-P., Brouet, J.-C., Mariette, X.
(1997). Lymphomas in Patients With Sjogren's Syndrome Are Marginal Zone B-Cell Neoplasms, Arise in Diverse Extranodal and Nodal Sites, and Are Not Associated With Viruses. Blood
90: 766-775
[Abstract][Full Text]
Fox, P.C., Speight, P.M.
(1996). Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjogren's Syndrome. CROBM
7: 144-158
[Abstract][Full Text]
Zelenetz, A. D., Diss, T.C., Pan, L.X., Isaacson, P.G.
(1993). Mucosa-Associated Lymphoid-Tissue Lymphoma. NEJM
329: 1657-1657
[Full Text]