Discoveries in cancer research are rarely so exceptional thatthey both cause immediate changes in the treatment of patientsand dramatically advance our understanding of the mechanismsunderlying the disease. However, observations of the strikingefficacy of all-trans-retinoic acid (tretinoin) in the treatmentof patients with acute promyelocytic leukemia, followed closelyby the discovery of a specific molecular genetic abnormalityin a retinoid receptor, have greatly expanded scientific insightabout leukemogenesis and have radically altered treatment strategiesin this illness. The observation of tumor cells undergoing maturationas a patient enters remission has also provided a remarkabledemonstration of drug-induced . . . [Full Text of this Article]
Background
Molecular Genetics of Acute Promyelocytic Leukemia
Retinoids, Retinoid Receptors, and the PML Gene
PML/RAR-alpha and Leukemogenesis
Clinical Activity of Retinoic Acid in Acute Promyelocytic Leukemia
Induction of Remission
Predictiveness of Clinical Response
Duration of Remission
Acquired Resistance
Mechanism of Action
Adverse Effects
Leukocytosis and the "Retinoic Acid Syndrome"
Treatment Recommendations in Acute Promyelocytic Leukemia
Assessment of Minimal Residual Disease
Summary
Source Information
From the Developmental Chemotherapy and Leukemia Services, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Cornell University Medical College, New York (R.P.W.); the Shanghai Institute of Hematology, Shanghai Second Medical University, People's Republic of China (Z.-Y.W.); and the Institut Universitaire d'Hematologie, Hopital St. Louis, University of Paris, Paris (H.T., L.D.).
Address reprint requests to Dr. Warrell at the Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021.
References
Appendix
Related Letters:
Acute Promyelocytic Leukemia
Stadler M., Ganser A., Hoelzer D., Izumi T., Hatake K., Miura Y., Warrell R. P., Degos L.
Extract |
Full Text
N Engl J Med 1994;
330:140-141, Jan 13, 1994.
Correspondence
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(2001). Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells. J. Immunol.
166: 5398-5406
[Abstract][Full Text]
Soignet, S. L.
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193: 521-530
[Abstract][Full Text]
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(2001). Retinoid Receptor Expression and Its Correlation to Retinoid Sensitivity in Non-M3 Acute Myeloid Leukemia Blast Cells. Clin. Cancer Res.
7: 367-373
[Abstract][Full Text]
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[Abstract][Full Text]
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(2001). Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer. J. Immunol.
166: 678-689
[Abstract][Full Text]
Douer, D., Estey, E., Santillana, S., Bennett, J. M., Lopez-Bernstein, G., Boehm, K., Williams, T.
(2001). Treatment of newly diagnosed and relapsed acute promyelocytic leukemia with intravenous liposomal all-trans retinoic acid. Blood
97: 73-80
[Abstract][Full Text]
Dimberg, A., Nilsson, K., Oberg, F.
(2000). Phosphorylation-deficient Stat1 inhibits retinoic acid-induced differentiation and cell cycle arrest in U-937 monoblasts. Blood
96: 2870-2878
[Abstract][Full Text]
Finch, R. A., Li, J., Chou, T-C., Sartorelli, A. C.
(2000). Maintenance of retinoic acid receptor alpha pools by granulocyte colony-stimulating factor and lithium chloride in all-trans retinoic acid-treated WEHI-3B leukemia cells: relevance to the synergistic induction of terminal differentiation. Blood
96: 2262-2268
[Abstract][Full Text]
Reddy, V., Moreb;, J., Padro, T., Berdel, W. E., Buchner, T., Mesters, R. M.
(2000). Prognostic correlation of increased angiogenesis in acute myeloid leukemia with cytogenetics. Blood
96: 1617-1618
[Full Text]
WAGNER, J., DECHOW, C., MORATH, C., LEHRKE, I., AMANN, K., WALDHERR, R., FLOEGE, J., RITZ, E.
(2000). Retinoic Acid Reduces Glomerular Injury in a Rat Model of Glomerular Damage. J. Am. Soc. Nephrol.
11: 1479-1487
[Abstract][Full Text]
Camacho, L. H., Soignet, S. L., Chanel, S., Ho, R., Heller, G., Scheinberg, D. A., Ellison, R., Warrell, R. P. Jr
(2000). Leukocytosis and the Retinoic Acid Syndrome in Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide. JCO
18: 2620-2625
[Abstract][Full Text]
Hansen, L. A., Sigman, C. C., Andreola, F., Ross, S. A., Kelloff, G. J., De Luca, L. M.
(2000). Retinoids in chemoprevention and differentiation therapy. Carcinogenesis
21: 1271-1279
[Abstract][Full Text]
Redner, R. L., Chen, J. D., Rush, E. A., Li, H., Pollock, S. L.
(2000). The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties. Blood
95: 2683-2690
[Abstract][Full Text]
Morschhauser, F., Cayuela, J. M., Martini, S., Baruchel, A., Rousselot, P., Socie, G., Berthou, P., Jouet, J. P., Straetmans, N., Sigaux, F., Fenaux, P., Preudhomme, C.
(2000). Evaluation of Minimal Residual Disease Using Reverse-Transcription Polymerase Chain Reaction in t(8;21) Acute Myeloid Leukemia: A Multicenter Study of 51 Patients. JCO
18: 788-788
[Abstract][Full Text]
Lin, B., Chen, G.-q., Xiao, D., Kolluri, S. K., Cao, X., Su, H., Zhang, X.-k.
(2000). Orphan Receptor COUP-TF Is Required for Induction of Retinoic Acid Receptor beta , Growth Inhibition, and Apoptosis by Retinoic Acid in Cancer Cells. Mol. Cell. Biol.
20: 957-970
[Abstract][Full Text]
Lowenberg, B., Downing, J. R., Burnett, A.
(1999). Acute Myeloid Leukemia. NEJM
341: 1051-1062
[Full Text]
Ailles, L. E., Gerhard, B., Kawagoe, H., Hogge, D. E.
(1999). Growth Characteristics of Acute Myelogenous Leukemia Progenitors That Initiate Malignant Hematopoiesis in Nonobese Diabetic/Severe Combined Immunodeficient Mice. Blood
94: 1761-1772
[Abstract][Full Text]
Chen, Y., Buck, J., Derguini, F.
(1999). Anhydroretinol Induces Oxidative Stress and Cell Death. Cancer Res.
59: 3985-3990
[Abstract][Full Text]
Le, X.-F., Groner, Y., Kornblau, S. M., Gu, Y., Hittelman, W. N., Levanon, D., Mehta, K., Arlinghaus, R. B., Chang, K.-S.
(1999). Regulation of AML2/CBFA3 in Hematopoietic Cells through the Retinoic Acid Receptor alpha -Dependent Signaling Pathway. J. Biol. Chem.
274: 21651-21658
[Abstract][Full Text]
Redner, R. L., Wang, J., Liu, J. M.
(1999). Chromatin Remodeling and Leukemia: New Therapeutic Paradigms. Blood
94: 417-428
[Full Text]
Rizvi, N. A., Marshall, J. L., Dahut, W., Ness, E., Truglia, J. A., Loewen, G., Gill, G. M., Ulm, E. H., Geiser, R., Jaunakais, D., Hawkins, M. J.
(1999). A Phase I Study of LGD1069 in Adults with Advanced Cancer. Clin. Cancer Res.
5: 1658-1664
[Abstract][Full Text]
Jansen, J.H., de Ridder, M.C., Geertsma, W.M.C., Erpelinck, C.A.J., van Lom, K., Smit, E.M.E., Slater, R., Reijden, B.A. v., de Greef, G.E., Sonneveld, P., Lowenberg, B.
(1999). Complete Remission of t(11;17) Positive Acute Promyelocytic Leukemia Induced by All-trans Retinoic Acid and Granulocyte Colony-Stimulating Factor. Blood
94: 39-45
[Abstract][Full Text]
Li, Y., Hashimoto, Y., Agadir, A., Kagechika, H., Zhang, X.-k.
(1999). Identification of a Novel Class of Retinoic Acid Receptor beta -Selective Retinoid Antagonists and Their Inhibitory Effects on AP-1 Activity and Retinoic Acid-induced Apoptosis in Human Breast Cancer Cells. J. Biol. Chem.
274: 15360-15366
[Abstract][Full Text]
Cheng, G.-X., Zhu, X.-H., Men, X.-Q., Wang, L., Huang, Q.-H., Jin, X. L., Xiong, S.-M., Zhu, J., Guo, W.-M., Chen, J.-Q., Xu, S.-F., So, E., Chan, L.-C., Waxman, S., Zelent, A., Chen, G.-Q., Dong, S., Liu, J.-X., Chen, S.-J.
(1999). Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha. Proc. Natl. Acad. Sci. USA
96: 6318-6323
[Abstract][Full Text]
Melnick, A., Licht, J. D.
(1999). Deconstructing a Disease: RAR{alpha}, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia. Blood
93: 3167-3215
[Full Text]
Lallemand-Breitenbach, V., Guillemin, M.-C., Janin, A., Daniel, M.-T., Degos, L., Kogan, S. C., Michael Bishop, J., de The, H.
(1999). Retinoic Acid and Arsenic Synergize to Eradicate Leukemic Cells in a Mouse Model of Acute Promyelocytic Leukemia. JEM
189: 1043-1052
[Abstract][Full Text]
Menell, J. S., Cesarman, G. M., Jacovina, A. T., McLaughlin, M. A., Lev, E. A., Hajjar, K. A.
(1999). Annexin II and Bleeding in Acute Promyelocytic Leukemia. NEJM
340: 994-1004
[Abstract][Full Text]
Muto, A., Kizaki, M., Yamato, K., Kawai, Y., Kamata-Matsushita, M., Ueno, H., Ohguchi, M., Nishihara, T., Koeffler, H. P., Ikeda, Y.
(1999). 1,25-Dihydroxyvitamin D3 Induces Differentiation of a Retinoic Acid-Resistant Acute Promyelocytic Leukemia Cell Line (UF-1) Associated With Expression of p21WAF1/CIP1 and p27KIP1. Blood
93: 2225-2233
[Abstract][Full Text]
Demetri, G. D., Fletcher, C. D. M., Mueller, E., Sarraf, P., Naujoks, R., Campbell, N., Spiegelman, B. M., Singer, S.
(1999). Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc. Natl. Acad. Sci. USA
96: 3951-3956
[Abstract][Full Text]
Grolleau, A., Sonenberg, N., Wietzerbin, J., Beretta, L.
(1999). Differential Regulation of 4E-BP1 and 4E-BP2, Two Repressors of Translation Initiation, During Human Myeloid Cell Differentiation. J. Immunol.
162: 3491-3497
[Abstract][Full Text]
Fanelli, M., Minucci, S., Gelmetti, V., Nervi, C., Gambacorti-Passerini, C., Pelicci, P. G.
(1999). Constitutive Degradation of PML/RARalpha Through the Proteasome Pathway Mediates Retinoic Acid Resistance. Blood
93: 1477-1481
[Abstract][Full Text]
Soignet, S. L., Maslak, P., Wang, Z.-G., Jhanwar, S., Calleja, E., Dardashti, L. J., Corso, D., DeBlasio, A., Gabrilove, J., Scheinberg, D. A., Pandolfi, P. P., Warrell, R. P.
(1998). Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide. NEJM
339: 1341-1348
[Abstract][Full Text]
Gallagher, R. E.
(1998). Arsenic -- New Life for an Old Potion. NEJM
339: 1389-1391
[Full Text]
NICOLLS, M. R., TERADA, L. S., TUDER, R. M., PRINDIVILLE, S. A., SCHWARZ, M. I.
(1998). Diffuse Alveolar Hemorrhage with Underlying Pulmonary Capillaritis in the Retinoic Acid Syndrome. Am. J. Respir. Crit. Care Med.
158: 1302-1305
[Abstract][Full Text]
Nervi, C., Ferrara, F. F., Fanelli, M., Rippo, M. R., Tomassini, B., Ferrucci, P. F., Ruthardt, M., Gelmetti, V., Gambacorti-Passerini, C., Diverio, D., Grignani, F., Pelicci, P. G., Testi, R.
(1998). Caspases Mediate Retinoic Acid-Induced Degradation of the Acute Promyelocytic Leukemia PML/RARalpha Fusion Protein. Blood
92: 2244-2251
[Abstract][Full Text]
Asou, H., Koike, M., Elstner, E., Cambell, M., Le, J., Uskokovic, M. R., Kamada, N., Koeffler, H. P.
(1998). 19-nor Vitamin-D Analogs: A New Class of Potent Inhibitors of Proliferation and Inducers of Differentiation of Human Myeloid Leukemia Cell Lines. Blood
92: 2441-2449
[Abstract][Full Text]
Shaknovich, R., Yeyati, P. L., Ivins, S., Melnick, A., Lempert, C., Waxman, S., Zelent, A., Licht, J. D.
(1998). The Promyelocytic Leukemia Zinc Finger Protein Affects Myeloid Cell Growth, Differentiation, and Apoptosis. Mol. Cell. Biol.
18: 5533-5545
[Abstract][Full Text]
Kurtz, T. W., Gardner, D. G.
(1998). Transcription-Modulating Drugs : A New Frontier in the Treatment of Essential Hypertension. Hypertension
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[Abstract][Full Text]
Yarovoi, S. V., Lu, X.-P., Picard, N., Rungta, D., Rideout, D., Pfahl, M.
(1998). Selective Activation of an Apoptotic Retinoid Precursor in Macrophage Cell Lines. J. Biol. Chem.
273: 20852-20859
[Abstract][Full Text]
Labrecque, J., Allan, D., Chambon, P., Iscove, N. N., Lohnes, D., Hoang, T.
(1998). Impaired Granulocytic Differentiation In Vitro in Hematopoietic Cells Lacking Retinoic Acid Receptors alpha 1 and gamma . Blood
92: 607-615
[Abstract][Full Text]
Seeler, J.-S., Marchio, A., Sitterlin, D., Transy, C., Dejean, A.
(1998). Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. Proc. Natl. Acad. Sci. USA
95: 7316-7321
[Abstract][Full Text]
Makishima, M., Umesono, K., Shudo, K., Naoe, T., Kishi, K., Honma, Y.
(1998). Induction of Differentiation in Acute Promyelocytic Leukemia Cells by 9-cis Retinoic Acid alpha -Tocopherol Ester (9-cis Tretinoin Tocoferil). Blood
91: 4715-4726
[Abstract][Full Text]
Roos, T. C., Jugert, F. K., Merk, H. F., Bickers, D. R.
(1998). Retinoid Metabolism in the Skin. Pharmacol. Rev.
50: 315-333
[Abstract][Full Text]
Gianni, M., Koken, M. H.M., Chelbi-Alix, M. K., Benoit, G., Lanotte, M., Chen, Z., de The, H.
(1998). Combined Arsenic and Retinoic Acid Treatment Enhances Differentiation and Apoptosis in Arsenic-Resistant NB4 Cells. Blood
91: 4300-4310
[Abstract][Full Text]
Barbui, T., Finazzi, G., Falanga, A.
(1998). The Impact of All-trans-Retinoic Acid on the Coagulopathy of Acute Promyelocytic Leukemia. Blood
91: 3093-3102
[Full Text]
Guidez, F., Ivins, S., Zhu, J., Soderstrom, M., Waxman, S., Zelent, A.
(1998). Reduced Retinoic Acid-Sensitivities of Nuclear Receptor Corepressor Binding to PML- and PLZF-RARalpha Underlie Molecular Pathogenesis and Treatment of Acute Promyelocytic Leukemia. Blood
91: 2634-2642
[Abstract][Full Text]
Matsushita, H., Kizaki, M., Kobayashi, H., Ueno, H., Muto, A., Takayama, N., Awaya, N., Kinjo, K., Hattori, Y., Ikeda, Y.
(1998). Restoration of Retinoid Sensitivity by MDR1 Ribozymes in Retinoic Acid-Resistant Myeloid Leukemic Cells. Blood
91: 2452-2458
[Abstract][Full Text]
Sugimoto, K., Yamada, K., Egashira, M., Yazaki, Y., Hirai, H., Kikuchi, A., Oshimi, K.
(1998). Temporal and Spatial Distribution of DNA Topoisomerase II Alters During Proliferation, Differentiation, and Apoptosis in HL-60 Cells. Blood
91: 1407-1417
[Abstract][Full Text]
Chelbi-Alix, M. K., Quignon, F., Pelicano, L., Koken, M. H. M., de The, H.
(1998). Resistance to Virus Infection Conferred by the Interferon-Induced Promyelocytic Leukemia Protein. J. Virol.
72: 1043-1051
[Abstract][Full Text]
Deaglio, S., Morra, M., Mallone, R., Ausiello, C. M., Prager, E., Garbarino, G., Dianzani, U., Stockinger, H., Malavasi, F.
(1998). Human CD38 (ADP-Ribosyl Cyclase) Is a Counter-Receptor of CD31, an Ig Superfamily Member. J. Immunol.
160: 395-402
[Abstract][Full Text]
Falini, B., Flenghi, L., Fagioli, M., Coco, F. L., Cordone, I., Diverio, D., Pasqualucci, L., Biondi, A., Riganelli, D., Orleth, A., Liso, A., Martelli, M. F., Pelicci, P.-G., Pileri, S.
(1997). Immunocytochemical Diagnosis of Acute Promyelocytic Leukemia (M3) With the Monoclonal Antibody PG-M3 (Anti-PML). Blood
90: 4046-4053
[Abstract][Full Text]
Li, X., Lopez-Guisa, J. M., Ninan, N., Weiner, E. J., Rauscher III, F. J., Marmorstein, R.
(1997). Overexpression, Purification, Characterization, and Crystallization of the BTB/POZ Domain from the PLZF Oncoprotein. J. Biol. Chem.
272: 27324-27329
[Abstract][Full Text]
Fenaux, P., Degos, L.
(1997). Differentiation Therapy for Acute Promyelocytic Leukemia. NEJM
337: 1076-1077
[Full Text]
Ferrucci, P. F., Grignani, F., Pearson, M., Fagioli, M., Nicoletti, I., Pelicci, P. G.
(1997). Cell death induction by the acute promyelocytic leukemia-specific PML/RARalpha fusion protein. Proc. Natl. Acad. Sci. USA
94: 10901-10906
[Abstract][Full Text]
Koken, M. H. M., Reid, A., Quignon, F., Chelbi-Alix, M. K., Davies, J. M., Kabarowski, J. H. S., Zhu, J., Dong, S., Chen, S.-J., Chen, Z., Tan, C. C., Licht, J., Waxman, S., de The, H., Zelent, A.
(1997). Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proc. Natl. Acad. Sci. USA
94: 10255-10260
[Abstract][Full Text]
Li, J.-Y., English, M. A., Ball, H. J., Yeyati, P. L., Waxman, S., Licht, J. D.
(1997). Sequence-specific DNA Binding and Transcriptional Regulation by the Promyelocytic Leukemia Zinc Finger Protein. J. Biol. Chem.
272: 22447-22455
[Abstract][Full Text]
Hong, S.-H., David, G., Wong, C.-W., Dejean, A., Privalsky, M. L.
(1997). SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha ) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA
94: 9028-9033
[Abstract][Full Text]
Gongora, C., David, G., Pintard, L., Tissot, C., Hua, T. D., Dejean, A., Mechti, N.
(1997). Molecular Cloning of a New Interferon-induced PML Nuclear Body-associated Protein. J. Biol. Chem.
272: 19457-19463
[Abstract][Full Text]
Tobita, T., Takeshita, A., Kitamura, K., Ohnishi, K., Yanagi, M., Hiraoka, A., Karasuno, T., Takeuchi, M., Miyawaki, S., Ueda, R., Naoe, T., Ohno, R.
(1997). Treatment With a New Synthetic Retinoid, Am80, of Acute Promyelocytic Leukemia Relapsed From Complete Remission Induced by All-trans Retinoic Acid. Blood
90: 967-973
[Abstract][Full Text]
Mandelli, F., Diverio, D., Avvisati, G., Luciano, A., Barbui, T., Bernasconi, C., Broccia, G., Cerri, R., Falda, M., Fioritoni, G., Leoni, F., Liso, V., Petti, M. C., Rodeghiero, F., Saglio, G., Vegna, M. L., Visani, G., Jehn, U., Willemze, R., Muus, P., Pelicci, P. G., Biondi, A., Lo Coco, F.
(1997). Molecular Remission in PML/RARalpha -Positive Acute Promyelocytic Leukemia by Combined All-trans Retinoic Acid and Idarubicin (AIDA) Therapy. Blood
90: 1014-1021
[Abstract][Full Text]
Benedetti, L., Levin, A. A., Scicchitano, B. M., Grignani, F., Allenby, G., Diverio, D., Lo Coco, F., Avvisati, G., Ruthardt, M., Adamo, S., Pelicci, P. G., Nervi, C.
(1997). Characterization of the Retinoid Binding Properties of the Major Fusion Products Present in Acute Promyelocytic Leukemia Cells. Blood
90: 1175-1185
[Abstract][Full Text]
Meloni, G., Diverio, D., Vignetti, M., Avvisati, G., Capria, S., Petti, M. C., Mandelli, F., Lo Coco, F.
(1997). Autologous Bone Marrow Transplantation for Acute Promyelocytic Leukemia in Second Remission: Prognostic Relevance of Pretransplant Minimal Residual Disease Assessment by Reverse-Transcription Polymerase Chain Reaction of the PML/RARalpha Fusion Gene. Blood
90: 1321-1325
[Abstract][Full Text]
Tenen, D. G., Hromas, R., Licht, J. D., Zhang, D.-E.
(1997). Transcription Factors, Normal Myeloid Development, and Leukemia. Blood
90: 489-519
[Full Text]
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