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Previous Volume 329:208-209 July 15, 1993 Number 3 Next

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To the Editor: I agree with the conclusions of Randhawa et al. (Dec. 10 issue)¹ that liver-biopsy specimens showing evidence of the expression of the EBER-1 gene may be useful for predicting the development of post-transplantation lymphoproliferative disease and for allowing the premorbid adjustment of immunomodulators. I was surprised, however, that neither the authors nor the editorialist² raised the issue of examining tissues other than liver as sentinel sites of latent Epstein-Barr virus (EBV). In their discussion, Randhawa et al. list oropharyngeal mucosa, lymph nodes, and circulating lymphocytes as sites of EBV latency. Indeed, only 7 of the 24 patients . . . [Full Text of this Article]

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