The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
Editorial
PreviousPrevious
Volume 329:658-660 August 26, 1993 Number 9
NextNext

The New and the Old -- Molecular Diagnostics and Hemolytic Disease of the Newborn

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited

More Information
-PubMed Citation
Hemolytic disease of the newborn occurs as a result of sensitization of the mother's immune system to red-cell antigens of the fetus. This sensitization results from the transplacental passage of fetal red cells possessing an antigen that is not present on maternal red cells. The IgG antibodies produced by the mother in response to the foreign antigen cross the placenta into the fetal circulation, bind to the red cells there, and destroy them. As a consequence of the hemolytic process, there is both extramedullary hematopoiesis and reticuloendothelial clearance of sensitized fetal cells, leading to hepatic and splenic enlargement. As the . . . [Full Text of this Article]

References



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2009 Massachusetts Medical Society. All rights reserved.