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Correspondence
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Volume 329:664-665 August 26, 1993 Number 9
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Graft-versus-Host Disease

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 by Shivdasani, R. A.
To the Editor: In their discussion of graft-versus-host disease (GVHD) associated with the transfusion of blood from unrelated HLA-homozygous donors, Shivdasani et al. (March 18 issue)1 cite data indicating that the risk of transfusion of blood from HLA homozygotes to HLA heterozygotes with a shared haplotype is 1 in 7174 among whites in the United States2. They misinterpret this to mean that the incidence of transfusion-associated GVHD "may be as high as 1 in 7174 among whites." If this were true, more than 1500 cases would occur in immunocompetent patients each year in the United States, since more than . . . [Full Text of this Article]

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