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Previous Volume 330:1081-1083 April 14, 1994 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Cardiovascular disease accounts for considerable mortality and morbidity in Western countries. Most of the common forms of cardiovascular disease, such as atherosclerosis, are caused by functional and structural changes in the blood-vessel wall. These changes include abnormal vasoconstriction, enhanced interaction of blood cells with the vessel wall, activation of coagulation mechanisms, and migration and proliferation of vascular smooth-muscle cells^1,2,3. Depending on the stage and location of the disease, one or more of these factors predominate. These vascular abnormalities have an important role in the pathogenesis of angina pectoris, myocardial infarction, stroke, and vascular forms of renal failure.

A crucial . . . [Full Text of this Article]

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