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Correspondence
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Volume 330:1090 April 14, 1994 Number 15
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Tumor Lysis Syndrome after Treatment of Chronic Lymphocytic Leukemia with Cladribine

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 by Dann, E. J.
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To the Editor: In the November 18 issue of the Journal, Dann et al.1 reported a case of tumor lysis syndrome after treatment with 2-chlorodeoxyadenosine (cladribine) in a patient with refractory chronic lymphocytic leukemia. We would like to report another case of tumor lysis syndrome resulting from treatment with 2-chlorodeoxyadenosine.

A 59-year-old man presented to the Mayo Clinic for a second opinion concerning therapy for his chronic myelogenous leukemia in chronic phase, which had been diagnosed approximately 18 months earlier. The patient could not tolerate hydroxyurea, had dose-limiting thrombocytopenia when treated with busulfan, and did not want to try interferon . . . [Full Text of this Article]

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