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Previous Volume 330:1241-1242 April 28, 1994 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Individual studies are seldom large enough to permit assessment of the shape of those dose-response relations between even common exposures and outcomes, such as alcohol intake and myocardial infarction. For example, the confidence intervals reported by Gaziano et al. (Dec. 16 issue)¹ were about 30 percent of the estimated relative risk at each dose. These are wide enough to be consistent not only with "the well-known U-shaped curve,"² but also with a linear downward slope, a threshold effect, or a saturation effect. My meta-analysis³ of 30 cohort studies of alcohol intake in relation to fatal or nonfatal . . . [Full Text of this Article]

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