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Worsening of asthma at night has been recognized since the earliest descriptions of the disease, but the mechanisms underlying this phenomenon have still not been fully explained. Nocturnal exacerbation is a very common feature of asthma. It may affect a large proportion of patients and is often unrecognized by doctors. Although it has been neglected by researchers for many years, there has been increasing interest in the phenomenon of nocturnal asthma over the past decade, for several reasons.
First and foremost, nocturnal asthma remains an important clinical problem, and patients with asthma are often troubled by nighttime symptoms even when
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