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Previous Volume 330:1450-1451 May 19, 1994 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Huntington's disease is an inherited neurodegenerative disease of midlife onset that produces a characteristic, progressive movement disorder with accompanying psychiatric changes. The symptoms result from the selective loss of neurons, most notably in the caudate nucleus and putamen, and there is currently no effective treatment. In 1983 we identified chromosome 4 as the site of the defect in Huntington's disease, triggering a decade-long search for the disease gene itself¹. In early 1993 the search ended with the discovery that the defect causing Huntington's disease is an expanded, unstable stretch of DNA with a repeating pattern of three nucleotide bases, . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Roses, A. D. (2001). Pharmacogenetics. Hum Mol Genet 10: 2261-2267 [Abstract] [Full Text]  
• Alper, J. S (1996). Genetic complexity in single gene diseases. BMJ 312: 196-197 [Full Text]