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Previous Volume 330:1526-1528 May 26, 1994 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In the 42 years since Ogden Bruton discovered agammaglobulinemia,¹ more than 50 additional immunodeficiency syndromes have been described². Until recently, there was little insight into the fundamental problems underlying most of these conditions. Within the past 16 months, however, the molecular bases of three X-linked immunodeficiency disorders -- X-linked hyper-IgM syndrome, X-linked agammaglobulinemia, and X-linked severe combined immunodeficiency -- have been reported³. These remarkable accomplishments have been made possible by a combination of new knowledge of molecular signaling mechanisms between and within cells of the immune system and greatly improved approaches to the mapping of disease loci within . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Kornfeld, S. J., Good, R. A., Litman, G. W., Parolini, O., Rohrer, J., Conley, M. E., Buckley, R. H. (1994). Atypical X-Linked Agammaglobulinemia. NEJM 331: 949-951 [Full Text]