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Volume 330:1530-1533 May 26, 1994 Number 21
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Picking a Research Problem -- The Critical Decision

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There is probably no question that plagues investigators, especially young investigators, more than how to pick a research project. This decision is not one that must be faced only once in a lifetime; rather, it must be continually revisited. Although it is easy to assume that success in research is just the difference between good and bad luck (and indeed there is a certain amount of luck in research), most highly regarded investigators will have many successful research experiences during their careers.

For the new investigator and junior faculty member just starting his or her career, the decision about a . . . [Full Text of this Article]

I. Anticipate the Results before Doing the First Study

II. Pick an Area on the Basis of the Interest of the Outcome

III. Look for an Underoccupied Niche That Has Potential

IV. Go to Talks and Read Papers outside Your Area of Interest

V. Build on a Theme

VI. Find a Balance between Low-Risk and High-Risk Projects, but Always Include a High-Risk, High-Interest Project in Your Portfolio

VII. Be Prepared to Pursue a Project to Any Depth Necessary

VIII. Differentiate Yourself from Your Mentor

IX. Do not Assume That Outstanding, or Even Good, Clinical Research Is Easier Than Outstanding Basic Research

X. Focus, Focus, Focus

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