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Previous Volume 330:1679-1681 June 9, 1994 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Phosphate plays a critical part in the regulation of cell metabolism, and phosphate homeostasis is closely regulated in normal humans. Indeed, like serum calcium, serum phosphate is maintained within a narrow range of values, and people with abnormal concentrations may have a predisposition to life-threatening conditions, such as hemolysis, myopathy, hypocalcemia, and nephrocalcinosis.

The principal organ that regulates phosphate homeostasis is the kidney. Regulation is accomplished partly through variation in glomerular filtration of phosphate but primarily through variation in renal tubular reabsorption of phosphate. These variations are detectable within 24 hours after a change in dietary phosphate intake and even . . . [Full Text of this Article]

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• Vargas, M. A., St-Louis, M., Desgroseillers, L., Charli, J.-L., Boileau, G. (2003). Parathyroid Hormone-Related Protein(1-34) Regulates Phex Expression in Osteoblasts through the Protein Kinase A Pathway. Endocrinology 144: 4876-4885 [Abstract] [Full Text]  
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• Williams, C P, Child, D F, Hudson, P R, Davies, G K, Davies, M G, John, R, Anandaram, P S, De Bolla, A R (2001). Why oral calcium supplements may reduce renal stone disease: report of a clinical pilot study. J. Clin. Pathol. 54: 54-62 [Abstract] [Full Text]  
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• Lipman, M. L., Panda, D., Bennett, H. P. J., Henderson, J. E., Shane, E., Shen, Y., Goltzman, D., Karaplis, A. C. (1998). Cloning of Human PEX cDNA. EXPRESSION, SUBCELLULAR LOCALIZATION, AND ENDOPEPTIDASE ACTIVITY. J. Biol. Chem. 273: 13729-13737 [Abstract] [Full Text]  
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