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A correction has been published: N Engl J Med 1994;331(8):559.

Review Article
Drug Therapy
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Volume 330:1731-1738 June 16, 1994 Number 24
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The Management of Hyperthyroidism
Jayne A. Franklyn

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Hyperthyroidism is common, affecting approximately 2 percent of women and 0.2 percent of men1. There are three principal treatments -- antithyroid drugs, radioiodine, and surgery -- all of which are effective, but opinions differ about the indications for them2 because no single treatment regularly results in permanent euthyroidism.

Investigation of Hyperthyroidism

When hyperthyroidism is suspected, the diagnosis should be confirmed by measurement of serum thyrotropin and total or free thyroxine, which are usually present in low and high concentrations, respectively (Figure 1)3. If the thyrotropin level is low but the thyroxine level is normal, serum triiodothyronine should be measured, . . . [Full Text of this Article]

Antithyroid Drugs

Indications for Antithyroid-Drug Therapy and Treatment Regimens

Side Effects

Outcome of Treatment

{beta}-Adrenergic-Antagonist Drugs

Inorganic Iodide

Radioiodine Therapy

Indications and Regimens

Post-Treatment Thyroid Function

Other Side Effects and Adjunctive Treatment

Ophthalmopathy

Cancer and Teratogenesis

Subtotal Thyroidectomy

Preparation and Adverse Effects

Postoperative Thyroid Function

Management of Toxic Adenoma or Toxic Nodular Goiter

Management of Hyperthyroidism Caused by Thyroiditis

Management of Hyperthyroidism in Pregnancy

Treatment of Thyrotoxic Crisis

Summary


Source Information

From the Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom, where reprint requests should be addressed to Dr. Franklyn.

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