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Correspondence
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Volume 330:1756-1757 June 16, 1994 Number 24
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Chemotherapy plus Surgery versus Surgery Alone in Non-Small-Cell Lung Cancer

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 by Rosell, R.
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To the Editor: We are concerned about several aspects of the study by Rosell et al. (Jan. 20 issue)1. The title is incorrect and misleading: the trial did not compare preoperative chemotherapy plus surgery with surgery alone; the trial compared preoperative chemotherapy plus surgery plus radiotherapy with surgery plus radiotherapy.

The rates of survival and disease-free survival were extremely poor in the surgery-plus-radiotherapy group. These rates would be expected among patients with metastatic non-small-cell lung cancer but are inferior to what would be expected in patients with resectable stage III disease. In several randomized trials, reviewed by Van Houtte,2 . . . [Full Text of this Article]

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