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Previous Volume 330:1789-1790 June 23, 1994 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease) is characterized by telangiectatic lesions of the nose, lips, and visceral organs including the liver, spleen, gastrointestinal tract, lungs, brain, and spinal cord^1,2,3,4,5. It is inherited as an autosomal dominant trait. Its most common manifestations are recurrent epistaxis and gastrointestinal bleeding, which can be life threatening⁶. Nasal bleeding has been treated by dermatoplasty of the nasal septa, photocoagulation, and amniotic-membrane grafts^6,7 and by the administration of estrogen and progesterone,^8,9 but these treatments are often ineffective.

Aminocaproic acid is a potent inhibitor of the fibrinolytic system. In low doses it blocks the conversion of . . . [Full Text of this Article]

Case Reports

Patient 1

Patient 2

Discussion

Source Information

From the Division of Medical Oncology and Hematology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine (H.I.S., L.A.L.), and James A. Haley Veterans Hospital (H.I.S., G.A.M., L.A.L.) -- both in Tampa, Fla.

Address reprint requests to Dr. Saba at the Division of Medical Oncology and Hematology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL 33612.

References

Related Letters:

Treatment of Bleeding in Hereditary Hemorrhagic Telangiectasia with Aminocaproic Acid
Korzenik J. R., Topazian M. D., White R., Saba H. I., Morelli G., Logrono L.
Extract | Full Text  
N Engl J Med 1994; 331:1236, Nov 3, 1994. Correspondence

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