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Editorial
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Volume 330:1822-1823 June 23, 1994 Number 25
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Stopping Bleeding in Hereditary Telangiectasia

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Hereditary hemorrhagic telangiectasia, also known as Rendu-Osler-Weber syndrome, is a familial disease in which telangiectases occur in the skin, mucosal surfaces, and solid organs1,2. Small telangiectases are a mild cosmetic problem, but larger lesions can be a source of chronic blood loss, systemic emboli, hypoxemia, hepatic dysfunction, and high-output cardiac failure. The treatment of troublesome telangiectasia in patients with this disease has always been difficult, because bleeding sites may be many and scattered. Treatment often requires multiple blood transfusions, large doses of iron, and various invasive procedures in order to make the diagnosis, staunch bleeding, or prevent recurrent hemorrhage. . . . [Full Text of this Article]

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