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Correspondence
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Volume 330:1832-1833 June 23, 1994 Number 25
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High Serum Gamma-Glutamyltransferase Concentrations in a Family

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To the Editor: Gamma-glutamyltransferase (GGT) is a glycoprotein enzyme that catalyzes the transfer of the gamma-glutamyl group from gamma-glutamyl peptides to other peptides and to l-amino acids. The activity of GGT in the kidney is very high; there is lower activity in the liver and pancreas. Patients with cholestasis usually have increased serum GGT concentrations, and the concentrations may be increased by certain enzyme-inducing drugs or alcohol abuse1,2,3. Measurements of serum GGT aid in interpreting elevated serum alkaline phosphatase values, since patients with skeletal disease have normal serum GGT values. GGT activity in serum is the sum of the . . . [Full Text of this Article]

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