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Previous Volume 330:1880-1886 June 30, 1994 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Fever is a complex, coordinated autonomic, neuroendocrine, and behavioral response that is adaptive and is used by nearly all vertebrates as part of the acute-phase reaction to immune challenge. Although the febrile response can be elicited by a wide variety of infectious organisms and may also occur during noninfectious inflammatory conditions, its manifestations are stereotyped and largely independent of the causative agent. Like other integrated responses, such as the regulation of energy metabolism, blood pressure and volume, and reproduction, fever depends on humoral cues from the body, is orchestrated largely by the hypothalamus, and involves the coordination of a wide . . . [Full Text of this Article]

Components of the Febrile Response

What Is the Signal for Initiating Fever?

How Does the Brain Recognize Circulating Endogenous Pyrogens?

How Is the Febrile Signal Relayed to Critical Structures in the Brain?

Implications for Medical Practice

Conclusion

Discussion

Source Information

From the Department of Neurology and Program in Neuroscience, Beth Israel Hospital and Harvard Medical School, Boston (C.B.S.), and the Committee on Neurobiology, University of Chicago, Chicago (C.D.B.).

Address reprint requests to Dr. Saper at the Department of Neurology, Beth Israel Hospital, 330 Brookline Ave., Boston, MA 02215.

References

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