Clostridium difficile, the agent that causes pseudomembranouscolitis associated with antibiotic therapy, has been identifiedin recent years as a common nosocomial pathogen. First describedin 1935 by Hall and O'Toole, this gram-positive anaerobic bacilluswas named "the difficult clostridium" because it resisted earlyattempts at isolation and grew very slowly in culture1. Althoughthe organism released potent toxins in broth culture, the factthat it was found in stool specimens from healthy neonates ledto its classification as a commensal. C. difficile subsequentlypassed into obscurity.
In the 1960s and 1970s antibiotic-associated pseudomembranouscolitis became a major clinical . . . [Full Text of this Article]
Pathogenesis
Epidemiology
Clinical Presentation
Laboratory Diagnosis
Treatment
Initial Therapy
Treatment of Recurrent Diarrhea from C. difficile Infection
Source Information
From the Section of Gastroenterology, Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston.
Address reprint requests to Dr. Kelly at Gastroenterology, E201, Boston University Medical Center, University Hospital, 88 E. Newton St., Boston, MA 02118.
References
Related Letters:
Clostridium difficile Colitis
Fang F. C., Madinger N. E., Berman D. S., Wenglin B. D., Goldman W. M., Avicolli A. S., Lutwick S., Kelly C. P., Pothoulakis C., Lamont J. T.
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N Engl J Med 1994;
330:1754-1755, Jun 16, 1994.
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