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Previous Volume 330:291 January 27, 1994 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their review article "Thrombolysis in Acute Myocardial Infarction" (Sept. 2 issue),¹ Anderson and Willerson state that "urokinase is a true enzyme . . . [that] exists in both double-chain and single-chain forms." This statement obscures the fundamental and clinically important differences between these two forms, a subject never made clear in this otherwise informative review.

Urokinase is a true enzyme. The single-chain form is, in fact, a proenzyme that is inert and stable in plasma (where it is naturally present) and does not form complexes with plasma inhibitors². Moreover, unlike urokinase, the proenzyme is relatively . . . [Full Text of this Article]

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