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Previous Volume 330:398-401 February 10, 1994 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Post-transfusion graft-versus-host disease (GVHD) is generally thought to result from the engraftment of lymphocytes in blood products^1,2. If circumstances permit, the donor's T lymphocytes mount an immune attack against the recipient's tissues. The clinical manifestations of the disorder are fever, rash, hepatitis, diarrhea, bone marrow aplasia, pancytopenia, and infection³. Post-transfusion GVHD can usually be diagnosed clinically during its florid stage. However, in its early stage, it is not easily differentiated from toxic shock syndrome, drug reactions, or viral infections. Early diagnosis may allow more effective treatment of the disease.

Post-transfusion GVHD occurs when the blood donor is homozygous . . . [Full Text of this Article]

Case Reports

Patient 1

Patient 2

Methods

Preparation of DNA

Primers

Detection of Polymorphic Alleles

Results

Discussion

Source Information

From the Department of Transfusion Medicine and Immunohematology (L.W., T.J., K. Tokunaga, K. Takahashi, S.K.), and the Department of Biochemistry and Nutrition (L.W., K. Takai), Faculty of Medicine, University of Tokyo, Bunkyo-ku; and the Japanese Red Cross Central Blood Center, Shibuya (K. Tokunaga, S.U., K. Tadokoro) -- both in Tokyo, Japan.

Address reprint requests to Ms. Wang at the Department of Research, Japanese Red Cross Central Blood Center, Hiroo 4-1-31, Shibuya-ku, Tokyo 150, Japan.

References

This article has been cited by other articles:

• Alter, H. J., Klein, H. G. (2008). The hazards of blood transfusion in historical perspective. Blood 112: 2617-2626 [Abstract] [Full Text]  
• WILLIAMSON, L. M (1998). Transfusion associated graft versus host disease and its prevention. Heart 80: 211-212 [Full Text]  
• Nishimura, M., Uchida, S., Mitsunaga, S., Yahagi, Y., Nakajima, K., Tadokoro, K., Juji, T. (1997). Characterization of T-Cell Clones Derived From Peripheral Blood Lymphocytes of a Patient With Transfusion-Associated Graft-Versus-Host Disease: Fas-Mediated Killing by CD4+ and CD8+ Cytotoxic T-Cell Clones and Tumor Necrosis Factor beta  Production by CD4+ T-Cell Clones. Blood 89: 1440-1445 [Abstract] [Full Text]