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Original Article
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Volume 330:469-471 February 17, 1994 Number 7
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Umbilical-Cord Ligation of an Acardiac Twin by Fetoscopy at 19 Weeks of Gestation
Ruben A. Quintero, Harry Reich, Karoline S. Puder, Mordechai Bardicef, Mark I. Evans, David B. Cotton, and Roberto Romero

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Twin reversed-arterial-perfusion sequence is a serious complication of monozygotic multiple gestations, affecting 1 percent of monozygotic twins, or 1 in 35,000 births1. It has been hypothesized that in the presence of artery-to-artery and vein-to-vein anastomoses in a monozygotic placenta, blood is perfused by the hemodynamically advantaged twin ("pump" twin) to the other twin ("recipient" twin) by means of retrograde flow2. Inadequate perfusion of the recipient twin is responsible for the development of a characteristic and invariably lethal set of anomalies, including acardia and acephalus. Typically, the pump twin is structurally normal, but it is at risk for in . . . [Full Text of this Article]

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From the Center for Fetal Diagnosis and Therapy, Fetal Endoscopy Program, Department of Obstetrics and Gynecology, Hutzel Hospital, Wayne State University, Detroit (R.A.Q., K.S.P., M.B., M.I.E., D.B.C., R.R.); Wyoming Valley Gyn Associates, Kingston, Pa. (H.R.); and the Perinatology Research Branch, National Institutes of Child Health and Human Development, Bethesda, Md. (R.R.).

Address reprint requests to Dr. Quintero at Hutzel Hospital, 4707 St. Antoine Blvd., Detroit, MI 48201.

References


Related Letters:

A Simpler Technique for Umbilical-Cord Blockade of an Acardiac Twin
Holzgreve W., Tercanli S., Krings W., Schuierer G., Quintero R. A.
Extract | Full Text  
N Engl J Med 1994; 331:56-57, Jul 7, 1994. Correspondence

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