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Previous Volume 330:507-509 February 17, 1994 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In a recent paper (Aug. 19 issue), Turpie et al. report a beneficial effect of adding aspirin to warfarin treatment for heart-valve recipients¹. We question the interpretation of this study.

The risk of major embolism among patients who received both aspirin and warfarin was 1.6 percent per year, a figure higher than those from the literature for treatment with oral anticoagulants only. Bloomfield et al.² found a 12-year cumulative risk of 8.8 percent, which corresponds to an annual incidence of about 0.8 percent (and not, as stated by Turpie et al., of 2 to 3 percent, . . . [Full Text of this Article]

References

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• Claassen, D. O., Kazemi, N., Zubkov, A. Y., Wijdicks, E. F. M., Rabinstein, A. A. (2008). Restarting Anticoagulation Therapy After Warfarin-Associated Intracerebral Hemorrhage. Arch Neurol 65: 1313-1318 [Abstract] [Full Text]  
• Kaplon, R. J., Cosgrove, D. M. III, Gillinov, A. M., Lytle, B. W., Blackstone, E. H., Smedira, N. G. (2000). Cardiac valve replacement in patients on dialysis: influence of prosthesis on survival. Ann. Thorac. Surg. 70: 438-441 [Abstract] [Full Text]  
• Sturzenegger, M., Beer, J. H., Rihs, F. (1995). Monitoring Combined Antithrombotic Treatments in Patients With Prosthetic Heart Valves Using Transcranial Doppler and Coagulation Markers. Stroke 26: 63-69 [Abstract] [Full Text]