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A correction has been published: N Engl J Med 1994;330(22):1627.

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Volume 330:509-510 February 17, 1994 Number 7
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Variation in the Prothrombin-Time Ratio during Oral Anticoagulation

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by Eckman, M. H.
To the Editor: The international normalized ratio (INR) is a value calculated to help determine the intensity of anticoagulation therapy based on the results of prothrombin-time tests performed by laboratories using different reagents with different normal ranges. Eckman et al. (Sept. 2 issue)1 suggest that adoption of the INR will address the economic and clinical effect of insufficient or excessive anticoagulation. Where INRs are not available, they advocate providing the clinician with the international sensitivity index (ISI) of the thromboplastin reagent used, so that clinicians can independently calculate the INR for each prothrombin-time result (INR = [prothrombin time divided by . . . [Full Text of this Article]

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