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Volume 330:573-574 February 24, 1994 Number 8
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Predictors of Mortality in Patients Undergoing Hemodialysis

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 by Owen, W. F.
To the Editor: Owen et al. (Sept. 30 issue)1 found that lower serum albumin concentrations were associated with an increased risk of death in patients with end-stage renal disease who were undergoing hemodialysis and concluded that poor nutrition was a major factor contributing to this increased mortality. We question this conclusion.

Serum albumin is often measured as part of a nutritional assessment, but as the authors noted, low serum albumin concentrations may be caused by many conditions other than malnutrition. In patients with inflammation, infection, or injury the catabolism and extravasation of albumin may be increased, and its synthesis decreased2. . . [Full Text of this Article]

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