To the Editor: The model of Shipp et al. for predicting survivalin patients with aggressive non-Hodgkin's lymphoma (Sept. 30issue)1 may represent an improvement over staging alone, butthe approximations that the authors use in simplifying theirmodel may limit its value in comparing different groups of treatedpatients or in assigning risk to an individual patient. Thegeneralizability of their results is limited by several factors.
First, the authors treat the relative risks of the five independentvariables as equal, whereas the true values vary by as muchas 14 percent from the mean.
De Paepe, P., Achten, R., Verhoef, G., Wlodarska, I., Stul, M., Vanhentenrijk, V., Praet, M., De Wolf-Peeters, C.
(2005). Large Cleaved and Immunoblastic Lymphoma May Represent Two Distinct Clinicopathologic Entities Within the Group of Diffuse Large B-Cell Lymphomas. JCO
23: 7060-7068
[Abstract][Full Text]