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Previous Volume 330:602-605 March 3, 1994 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Castleman's disease (angiofollicular lymphoid hyperplasia) is a heterogeneous group of lymphoproliferative disorders of uncertain cause¹. Two pathologic types, hyaline vascular and plasma-cell disease, have been recognized. The plasma-cell variant of Castleman's disease may be localized or multicentric. Multicentric disease is a systemic lymphoproliferative disorder characterized by lymphadenopathy, hepatosplenomegaly, and constitutional symptoms. Anemia, hypoalbuminemia, and hypergammaglobulinemia are also common. Interleukin-6, a cytokine with pleiotropic effects on the immune system, hematopoiesis, and acute-phase reactions, is a putative growth factor in multiple myeloma and may also be central to the pathophysiology of Castleman's disease^2,3,4,5,6,7. Administration of a murine anti-interleukin-6 monoclonal antibody . . . [Full Text of this Article]

Methods

Case Report

Discussion

Source Information

From the Departments of Medicine and Pathology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences (J.T.B., D.V., K.H., S.J., B.B.), and the Department of Pathology, John L. McClellan Memorial Veterans Hospital (S.-M.H.) -- both in Little Rock; the Department of Hematology, Centre Hospitalier Universitaire, Nantes, France (R.B., B.K.); and the Innotherapie Laboratoires, Besancon, France (J.W.).

Address reprint requests to Dr. Barlogie at the University of Arkansas for Medical Sciences, Slot 508, 4301 W. Markham, Little Rock, AR 72205.

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