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Previous Volume 330:646-647 March 3, 1994 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Transplantation of solid-organ allografts can induce long-term donor-type microchimerism¹ by migration of passenger mononuclear cells^2,3. So far, microchimerism has been described only in immunologically stable patients after liver or kidney transplantation⁴. An association between persistent chimerism and graft acceptance has been suggested. We describe persistent donor-type microchimerism in a patient with therapy-resistant graft rejection late after liver transplantation.

In December 1984 a 17-year-old boy (HLA-A1,11; B7,8; Cw7; DRw15,w17) received a liver transplant (Donor 1: HLA-A1,25; B18,w52; DR1,4) for end-stage primary sclerosing cholangitis. After an early episode of rejection that responded to steroids, he had an . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Alexander, S. I., Smith, N., Hu, M., Verran, D., Shun, A., Dorney, S., Smith, A., Webster, B., Shaw, P. J., Lammi, A., Stormon, M. O. (2008). Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant. NEJM 358: 369-374 [Abstract] [Full Text]  
• Harmon, J. V., Gruessner, A. C., Nakhleh, R. E., Zhang, K., Gruessner, R. W. G. (2001). Experimental Short-term Immunosuppression After Bowel Transplantation and Donor-Specific Bone Marrow Infusion. Arch Surg 136: 817-821 [Abstract] [Full Text]  
• Zhang, J., Tong, K.-L., Li, P. K.T., Chan, A. Y.W., Yeung, C.-K., Pang, C. C.P., Wong, T. Y.H., Lee, K.-C., Lo, Y.M. D. (1999). Presence of Donor- and Recipient-derived DNA in Cell-free Urine Samples of Renal Transplantation Recipients: Urinary DNA Chimerism. Clin. Chem. 45: 1741-1746 [Abstract] [Full Text]  
• Sarnacki, S, Nakai, H, Calise, D, Azuma, T, Brousse, N, Revillon, Y, Cerf-Bensussan, N (1998). Decreased expression of the interleukin 2 receptor on CD8 recipient lymphocytes in intestinal grafts rendered tolerant by liver transplantation in rats. Gut 43: 849-855 [Abstract] [Full Text]