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Previous Volume 331:57-58 July 7, 1994 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The neuropsychiatric side effects of the antimalarial drug mefloquine are well documented^1,2. They include anxiety, depression, hallucinations, acute psychosis, and seizures. The incidence of these side effects is 1 in 13,000 with prophylactic use and 1 in 250 with therapeutic use². The mechanism of action is unknown¹.

A 47-year-old, previously healthy Japanese tourist was admitted to our hospital because of severe falciparum malaria with parasitemia of 24 percent after a trip to Zaire without any antimalarial chemoprophylaxis. Treatment consisted of 750 mg of quinine per day and 450 mg of clindamycin three times daily . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Griffith, K. S., Lewis, L. S., Mali, S., Parise, M. E. (2007). Treatment of Malaria in the United States: A Systematic Review. JAMA 297: 2264-2277 [Abstract] [Full Text]  
• Dow, G. S., Koenig, M. L., Wolf, L., Gerena, L., Lopez-Sanchez, M., Hudson, T. H., Bhattacharjee, A. K. (2004). The Antimalarial Potential of 4-Quinolinecarbinolamines May Be Limited due to Neurotoxicity and Cross-Resistance in Mefloquine-Resistant Plasmodium falciparum Strains. Antimicrob. Agents Chemother. 48: 2624-2632 [Abstract] [Full Text]  
• JAVORSKY, D. J., TREMONT, G., KEITNER, G. I., PARMENTIER, A. H. (2001). Cognitive and Neuropsychiatric Side Effects of Mefloquine. J. Neuropsychiatry Clin. Neurosi. 13: 302-302 [Full Text]