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Previous Volume 331:746-747 September 15, 1994 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Elevated levels of fetal hemoglobin may diminish the severity of the -hemoglobinopathies sickle cell disease and -thalassemia. In -thalassemia, this effect is related to a reduction in the overall imbalance in the ratio of -globin and non--globin chains. In sickle cell anemia, an elevated level of fetal hemoglobin results in a reciprocal decrease in the intracellular concentration of hemoglobin S and inhibits polymer formation. The discovery that butyric acid is an inducer of fetal hemoglobin arose from the observation that the switch from hemoglobin F to hemoglobin A is delayed in infants of diabetic mothers. In . . . [Full Text of this Article]

References

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• Vadolas, J., Wardan, H., Orford, M., Voullaire, L., Zaibak, F., Williamson, R., Ioannou, P. A. (2002). Development of sensitive fluorescent assays for embryonic and fetal hemoglobin inducers using the human beta -globin locus in erythropoietic cells. Blood 100: 4209-4216 [Abstract] [Full Text]