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Previous Volume 331:1021-1022 October 13, 1994 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The serotonin syndrome consists of behavioral, neuromuscular, and autonomic changes that result from increased activity of serotonin (5-hydroxytryptamine) in the central nervous system.¹ Its symptoms and signs include confusion, fever, diaphoresis, hyperreflexia, ataxia, and myoclonus. The syndrome usually results from the concurrent use of two serotonergic medications, most often a monoamine oxidase inhibitor and either tryptophan or an inhibitor of serotonin reuptake, such as fluoxetine (Prozac) or sertraline (Zoloft). Because of the long-lasting serotonergic activity of both monoamine oxidase inhibitors and inhibitors of serotonin reuptake, however, the syndrome can occur when one drug is discontinued and the . . . [Full Text of this Article]

References

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• Velez, L. I, Shepherd, G., Roth, B. A, Benitez, F. L (2004). Serotonin Syndrome with Elevated Paroxetine Concentrations. The Annals of Pharmacotherapy 38: 269-272 [Abstract] [Full Text]  
• Birmes, P., Coppin, D., Schmitt, L., Lauque, D. (2003). Serotonin syndrome: a brief review. CMAJ 168: 1439-1442 [Full Text]  
• Pan, J.-J., Shen, W. W (2003). Serotonin Syndrome Induced by Low-Dose Venlafaxine. The Annals of Pharmacotherapy 37: 209-211 [Abstract] [Full Text]  
• Arnold, D. H. (2002). Consultation With the Specialist: The Central Serotonin Syndrome: Paradigm for Psychotherapeutic Misadventure. Pediatr. Rev. 23: 427-432 [Full Text]  
• Chambost, M., Liron, L., Peillon, D., Combe, C. (2000). Syndrome serotoninergique lors d'une intoxication par la fluoxetine chez une patiente prenant du moclobemide. Canadian J. Anesthesia 47: 246-250 [Abstract] [Full Text]