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Previous Volume 331:1236 November 3, 1994 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We read the Brief Report by Saba et al. (June 23 issue)¹ on the treatment of bleeding in hereditary hemorrhagic telangiectasia with aminocaproic acid with a mixture of hope and concern. Although Saba and colleagues had success with aminocaproic acid, we know of three patients with hereditary hemorrhagic telangiectasia in whom aminocaproic acid failed to decrease bleeding.

Patient 1 was a 66-year-old man whose primary manifestation of hereditary hemorrhagic telangiectasia was chronic gastrointestinal bleeding from gastric and small-bowel telangiectasias. His bleeding persisted despite trials of estrogen and progesterone, danazol, testosterone, and oral norepinephrine in addition to multiple . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Sabba, C., Gallitelli, M., Palasciano, G. (2001). Efficacy of Unusually High Doses of Tranexamic Acid for the Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia. NEJM 345: 926-926 [Full Text]  
• Shovlin, C. L, Letarte, M. (1999). Rare diseases bullet 4: Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms. Thorax 54: 714-729 [Full Text]  
• Haitjema, T., Westermann, C. J. J., Overtoom, T. T. C., Timmer, R., Disch, F., Mauser, H., Lammers, J.-W. J. (1996). Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Disease) New Insights in Pathogenesis, Complications, and Treatment. Arch Intern Med 156: 714-719 [Abstract]